2型糖尿病胰岛β细胞损伤机制的研究现状  

Research status of mechanisms of pancreatic islet beta cell injury in type 2 diabetes

作　　者：翟艳会 梁永林 安冬 张媛媛 苏菲 关晓文 朱向东 ZHAI Yan-hui;LIANG Yong-lin;AN Dong;ZHANG Yuan-yuan;SU Fei;GUAN Xiao-wen;ZHU Xiang-dong(Basic Medical College,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Institute of Traditional Chinese Medicine,Ningxia Medical University,Yinchuan 750004,Ningxia Hui Autonomous Region,China)

机构地区：[1]甘肃中医药大学基础医学院,甘肃兰州730000 [2]宁夏医科大学中医学院,宁夏回族自治区银川750004

出　　处：《中国临床药理学杂志》2024年第16期2442-2446,共5页The Chinese Journal of Clinical Pharmacology

基　　金：甘肃省科技厅教育科技创新基金资助项目(2021CYZC-03);宁夏回族自治区重点研发计划基金资助项目(2022BEG02034)。

摘　　要：2型糖尿病(T2DM)占所有糖尿病(DM)的90%以上,而胰岛β细胞质量下降与功能障碍是T2DM的核心环节,伴随病程延长β细胞数量功能逐渐衰减,其损伤机制涉及代谢应激、胰岛素分泌调节异常、胰岛微环境改变、线粒体损伤、糖脂毒性以及胰岛β细胞去分化等,因此对T2DM胰岛β细胞损伤机制进行总结阐述,以期对T2DM的精准干预提供参考依据。The number of type 2 diabetes(T2DM)accounts for more than 90%of all Diabetes mellitus(DM).The decrease of isletβcell mass and dysfunction are the core links of T2DM.With the prolongation of the course of disease,the number and function ofβcells are gradually attenuated,and the damage mechanism has not been elucidated.At present,it is believed that it is closely related to metabolic stress,abnormal regulation of insulin secretion,changes in islet microenvironment,mitochondrial damage,glycolipid toxicity and dedifferentiation of isletβcells.Therefore,the mechanism of isletβcell damage in T2DM is summarized and elaborated in order to provide some reference for the precise intervention of T2DM.

关 键 词：2型糖尿病 胰岛Β细胞 损伤机制 

分 类 号：R97[医药卫生—药品]