羧基化多壁碳纳米管修饰电极测定左氧氟沙星  

Determination of Levofloxacin on Carboxylated Multi-Wall Carbon Nanotubes Modified Glassy Carbon Electrode

作　　者：王莹[1] 马冬云[2] 沈景辉 景文慧 赵丽曼 袁寰[1] 李炳寅 WANG Ying;MA Dongyun;SHEN Jinghui;JING Wenhui;ZHAO Liman;YUAN Huan;LI Bingyin(College of Pharmacy,Jiamusi University,Jiamusi 154007,Heilongjiang China;Chemical Engineering Department Fuxin Higher Training College,Fuxin 123001,Liaoning China)

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007 [2]辽宁阜新高等专科学校化工系,辽宁阜新123001

出　　处：《吉首大学学报（自然科学版）》2024年第4期76-81,共6页Journal of Jishou University(Natural Sciences Edition)

基　　金：黑龙江省卫生厅项目(2019285);黑龙江省大学生创新创业项目(2021102221)。

摘　　要：探究了左氧氟沙星在羧基化多壁碳纳米管(c-MWCNTs)修饰电极上的电化学行为,并采用循环伏安法对左氧氟沙星含量进行了测定.结果表明,c-MWCNTs修饰电极对左氧氟沙星有明显的电催化作用;在pH值为5.0的NaH_(2)PO_(4)Na_(2)HPO_(4)缓冲溶液中,左氧氟沙星溶液的氧化峰电流与浓度在1×10^(-5)~4×10^(-4)mol/L范围内呈良好线性关系,相关系数为0.998,检出限为2.87×10^(-6)mol/L;在最优测试条件下,左氧氟沙星片剂的加标回收率为98.7%~103.0%,相对标准偏差为1.31%~3.99%(n=5);羧基化多壁碳纳米管修饰玻碳电极(c-MWCNTs/GCE)对左氧氟沙星有较好的电化学响应,灵敏度高,可用于药品中左氧氟沙星测定.Electrochemical behavior of levofloxacin on carboxylated multi-walled carbon nanotubes(c-MWCNTs)modified glassy carbon electrode(c-MWCNTs/GCE)was studied,and the content of levofloxacin was determinated.The results showed that the electrode had good electrocatalysis to levofloxacin.In a mixed phosphate(NaH_(2)PO_(4)-Na_(2)HPO_(4))buffer solution with pH 5.0,the excellent linear relationship was kept between oxidation peak currents and the concentration of levofloxacin in the range of 1×10^(-5)~4×10^(-4)mol/L with the correlation coefficient of 0.998,and the detection limit of 2.87×10^(-6)mol/L.Under the optimal test conditions,the recoveries of levofloxacin tablets were 98.7%~103.0%,and the relative standard deviation values of determination results were 1.31%~3.99%(n=5).Thus the c-MWCNTs/GCE has good electrochemical response to levofloxacin with high sensitivity and can be used for determination of levofloxacin content in drugs.

关 键 词：左氧氟沙星 电化学分析 羧基化碳纳米管 玻碳电极 

分 类 号：Q657.1[生物学—生物物理学] R917[医药卫生—药物分析学]