病灶内注射5-氟尿嘧啶治疗跖疣的临床效果观察  

Clinical Effect of Intralesional Injection of 5-Fluorouracil in the Treatment of Plantar Warts

作　　者：孙芳 郑晓明 曾彦超[3] 徐平 朱郧鑫 SUN Fang;ZHENG Xiao-ming;ZENG Yan-chao;XU Ping;ZHU Yun-xin(Department of Dermatology,Taihe Hospital,Hu-bei University of Medicine;Central Operating Room,Taihe Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China;Operating Room of Department of Anesthesiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]十堰市太和医院·湖北医药学院附属医院皮肤科 [2]十堰市太和医院·湖北医药学院附属医院中心手术室,湖北十堰442000 [3]重庆医科大学附属第一医院麻醉科手术室,重庆400016

出　　处：《湖北医药学院学报》2024年第4期416-421,共6页Journal of Hubei University of Medicine

基　　金：湖北省教育厅哲学社会科学项目(21Q194);重庆医科大学附属第一医院护理基金(HLJJ2019-11);重庆医科大学附属第一医院捐赠项目(YEZX-09)

摘　　要：目的:观察追踪病灶内注射5-氟尿嘧啶治疗跖疣的临床效果。方法:选取2019年12月至2022年12月某三甲医院皮肤科收治的140名跖疣患者为研究对象,根据治疗方案将患者分为病灶内注射5-氟尿嘧啶组(简称注射组)70例和病灶外敷5-氟尿嘧啶组(简称外敷组)70例,回顾性分析两组患者治疗期(6周)内跖疣临床治疗效果和治疗期结束后12周皮损状况,追踪跖疣复发率、瘢痕存留等差异。结果:在治疗周期内,注射组疼痛效果评分显著低于外敷组(P<0.05)且疼痛程度较治疗前显著降低;治疗期结束后注射组治疗总有效率为98.6%,显著高于外敷组的75.7%(P<0.05);两组皮损面积在治疗3周后出现显著差异,注射组皮损存留少于外敷组,且皮损面积改善早于外敷组;治疗期结束后12周总复发率比较,注射组为1.4%,低于外敷组的22.9%(P<0.05);在瘢痕存留率、不良反应发生率比较中,两组数据无明显统计学意义(P>0.05)。结论:病灶内注射5-氟尿嘧啶治疗跖疣在患者疼痛程度、治疗有效率、单位时间治疗皮损面积、复发率的评价指标中表现出优于外敷治疗的效果,有一定的临床推广意义;两种用药方式在跖疣瘢痕存留和治疗期药物不良反应的结果评价中,未体现明显差异且安全性尚可。Objective To observe the clinical effect of intralesional injection of 5-fluorouracil in the treatment of plantar warts.Methods A total of 140 patients with plantar warts admitted to the Department of Dermatology of a tertiary hospital from December 2019 to December 2022 were selected and divided into an intralesional injection group(injection group,70 cases)and an external application group(external application group,70 cases)according to the treatment plan.A retro⁃spective analysis was conducted on the clinical treatment effect of plantar warts during the treatment period(6 weeks)and the skin lesion condition 12 weeks after treatment between the two groups.Differences in the recurrence of plantar warts and scar left were observed.Results During the treatment,the pain effect score of the injection group was lower than that of the external application group(P<0.05),and the degree of pain was significantly reduced compared with the condition before treatment.After treatment,the total effective rate of the injection group was 98.6%,higher than the 75.7%of the external application group(P<0.05).There was a distinct difference in the area of skin lesions between the two groups after 3 weeks of treatment.The injection group had fewer skin lesions left and the improvement was earlier observed than that in the exter⁃nal application group.After 12 weeks of treatment,the total recurrence rate in the injection group was 1.4%,lower than the 22.9%in the external application group(P<0.05).No differences were found between the two groups in scar left and the incidence of adverse reactions(P>0.05).Conclusion In the treatment of plantar warts,intralesional injection of 5-flu⁃orouracil was superior to external application in evaluating patient pain,treatment efficacy,lesion area per unit time,and recurrence.,which is of certain significance for clinical promotion.The two methods demonstrate no significant differences in the evaluation of scar left and adverse drug reactions during the treatment of plantar warts,with accepta

关 键 词：5-氟尿嘧啶 跖疣治疗 效果观察 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]