基于Ni纳米颗粒的SERS基底制备及其性能  

Preparation of SERS Substrate Based on Ni Nanoparticles and Its Performance

作　　者：疏港 陈福彬[1] 张烨 苏艳梅[2] 张冶金[2] 潘教青[2] Shu Gang;Chen Fubin;Zhang Ye;Su Yanmei;Zhang Yejin;Pan Jiaoqing(School of Automation,Beijing Information Science and Technology University,Beijing 100101,China;Institute of Semiconductors,Chinese Academy of Sciences,Beijing 100083,China)

机构地区：[1]北京信息科技大学自动化学院,北京100101 [2]中国科学院半导体研究所,北京100083

出　　处：《微纳电子技术》2024年第9期118-124,共7页Micronanoelectronic Technology

基　　金：国家自然科学基金(62274153);国家自然科学基金委重大课题(62090053);北京市自然科学基金(4222078);北京市重点基金(Z200006)。

摘　　要：以Ni纳米材料为研究对象,提出了一种新的基于超声辅助的表面增强Raman散射(SERS)基底的制备方法,以实现对生物分子罗丹明6G(R6G)的高灵敏检测。首先,通过超声辅助法制备Ni纳米溶液,然后,采用旋涂法制备SERS基底,以R6G为探针分子,研究了基底的SERS活性、重复性以及在基底制备过程中加入表面活性剂甲基丙烯酸甲酯(MMA)对基底SERS活性的影响。结果表明,在加入MMA的实验条件下,基底表面的纳米颗粒分散更加均匀,能提供的SERS热点更多,有助于增强基底的SERS强度。该SERS基底对R6G的最低检测限(LOD)为1×10^(-6)mol/L,增强因子约为2.56×10^(4),重复性测试的相对标准偏差为10.19%(R6G浓度为1×10^(4)mol/L)。该方法经济、简单、快速、有效,可以作为未来生物传感应用的候选方法。A novel ultrasound-assisted preparation method based on surface-enhanced Raman scattering(SERS)substrates was proposed to realize the highly sensitive detection of the biomolecule Rhodamine 6G(R6G)using Ni nanomaterials.Firstly,Ni nanosolutions were prepared by ultrasound-assisted method.Then,the spin-coating method was used to prepare SERS substrates.R6G was used as a probe molecule,and the SERS activity and reproducibility of the substrate,as well as the effect of the addition of the surfactant methyl methacrylate(MMA)on its SERS activity during the substrate preparation were investigated.The results show that under the experimental conditions with the addition of MMA,the nanoparticles on the surface of the substrate are more uniformly dispersed and provids more SERS hotspots,which contributes to the enhancement of the SERS intensity of the substrate.The lowest limit of detection(LOD)of the SERS substrate for R6G is 1×10^(-6)mol/L,the enhancement factor is about 2.56×104,and the relative standard deviation of the reproducibility test is 10.19%(1×10^(4)mol/L R6G).The method is economical,simple,rapid,and effective,and can be a potential candidate for future biosensing applications.

关 键 词：表面增强Raman散射(SERS) Ni纳米颗粒 超声辅助 罗丹明6G(R6G) 表面活性剂 

分 类 号：O657.37[理学—分析化学]