基于营卫学说探讨巨噬细胞极化在肺纤维化中的作用  

Exploration of Macrophage Polarization Role in Pulmonary Fibrosis Based on the Yingwei Theory

作　　者：孙艳 范佳欣 刘石 唐梦娟 李妲[2] SUN Yan;FAN Jiaxin;LIU Shi;TANG Mengjuan;LI Da(First Clinical College of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学第一中医临床学院,湖南长沙410208 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《现代中医药》2024年第5期1-5,共5页Modern Chinese Medicine

基　　金：湖南省自然科学基金青年基金项目(2023JJ40501);湖南省卫健委重点项目(202203023299);长沙市自然科学基金项目(kq2202455)。

摘　　要：近年来,肺纤维化(PF)的发病率明显上升,随着新型冠状病毒的传播,PF患者的肺部纤维化进展迅速,该疾病日渐受到学者的重视。已有研究提出PF的发生与免疫细胞密切相关,巨噬细胞作为免疫细胞的重要组成部分,对维持肺部微环境稳定,修复受损组织发挥着重要作用。巨噬细胞在不同的微环境刺激下可极化成两种不同的表型,经典激活途径巨噬细胞(M1)和替代激活途径巨噬细胞(M2),二者在PF的不同阶段具有不同的作用,与中医营卫学说在组成、作用、病理特征、分布等方面高度相似。因此,文章通过营卫学说探讨巨噬细胞极化在肺纤维化中的作用,意为拓展营卫学说的应用范围,也为肺纤维化的中西医结合治疗方案提供思路和理论支持。In recent years,the incidence rate of pulmonary fibrosis(PF)has gradually increased due to environmental pollution and the limitation of treatment methods.With the spread of COVID-19,the pulmonary fibrosis of PF patients has progressed rapidly,and the disease has increasingly attracted the attention of scholars.Previous studies have suggested that the occurrence of PF is closely related to immune cells.Macrophages,as an important component of immune cells,play a crucial role in maintaining the stability of the lung microenvironment and repairing damaged tissues.Macrophages can polarize into two different phenotypes under different microenvironment stimuli:classical activation pathway macrophages(M1)and alternative activation pathway macrophages(M2).The two have different roles in different stages of PF and are highly similar to the traditional Chinese medicine theory of health in terms of composition,function,pathological characteristics,and distribution.Therefore,the article explores the role of macrophage polarization in pulmonary fibrosis through the theory of Yingwei,aiming to expand the application scope of Yingwei theory and provide ideas and theoretical support for the integrated treatment of pulmonary fibrosis with traditional Chinese and Western medicine.

关 键 词：营卫学说 巨噬细胞 巨噬细胞极化 中医药 肺纤维化 

分 类 号：R2-03[医药卫生—中医学]