益气化痰解毒抗癌方对非小细胞肺癌患者生存质量的影响  

Effect of Yiqi Huatan Jiedu Anticancer Formula on the Quality of Life of Non-Small Cell Lung Cancer Patients

作　　者：熊梦婷 李映霞[2] 徐超[2] 张元兵[2] 王开盛 XIONG Mengting;LI Yingxia;XU Chao;ZHANG Yuanbing;WANG Kaisheng(Jiangxi Provincial Hospital of Traditional Chinese and Western Medicine,Nanchang 330003,China;Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China;Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西省中西医结合医院,江西南昌330003 [2]江西中医药大学附属医院,江西南昌330006 [3]江西中医药大学,江西南昌330004

出　　处：《现代中医药》2024年第5期67-72,共6页Modern Chinese Medicine

基　　金：2022年度江西省卫生健康委科技计划项目(202210763);中医肺科学江西省重点实验室(赣科发财字[2024]18号)。

摘　　要：目的观察益气化痰解毒抗癌方对非小细胞肺癌患者生存质量的影响。方法纳入符合标准的患者并按照随机数表法分为治疗组和对照组各30例。对照组给予分子靶向药物吉非替尼片口服;治疗组在对照组的基础上联合服用益气化痰解毒抗癌方。对比两组中医证候疗效、卡氏评分、生活质量测定量表积分变化及靶向药物常见不良反应发生率及严重程度。结果治疗后,治疗组中医证候疗效明显优于对照组(P<0.05),治疗组卡氏评分均值提高,与对照组相比存在显著差异,差异有统计学意义(P<0.05)。生活质量测定量表中功能领域对比,两组在躯体领域、角色领域两个方面存在显著差异(P<0.05);症状子集对比,两组在疲倦、食欲、腹泻的症状中存在差异(P<0.05)。不良反应对比,两组不良反应的程度分级及发生率存在显著差异(P<0.05)。结论益气化痰解毒抗癌方能较好地改善非小细胞肺癌(气虚痰阻毒结证)患者临床症状,提高生活质量,既安全可靠又减毒增效。Objective To observe the effect of Yiqi Huatan Jiedu Anticancer Formula on the quality of life of patients with non-small cell lung cancer.Methods Patients who met the criteria were included and randomly divided into a treatment group and a control group,with 30 cases in each group.The control group was given the molecular targeted drug gefitinib tablets orally;The treatment group took a combination of Qi tonifying,phlegm resolving,detoxifying,and anti-cancer formula on the basis of the control group.Compare the efficacy of two groups of traditional Chinese medicine syndromes,changes in Karnofsky score,quality of life measurement scale scores,and the incidence and severity of common adverse reactions of targeted drugs.Results After treatment,the therapeutic effect of traditional Chinese medicine syndrome in the treatment group was significantly better than that in the control group(P<0.05).The mean score of Karnofsky in the treatment group increased,and there was a significant difference compared with the control group,with statistical significance(P<0.05).In the comparison of functional domains in the quality of life measurement scale,there were significant differences between the two groups in the physical domain and role domain(P<0.05);Comparison of symptom subsets showed significant differences between the two groups in symptoms of fatigue,appetite,and diarrhea(P<0.05).There was a significant difference in the grading and incidence of adverse reactions between the two groups(P<0.05).Conclusion The formula for nourishing Qi,resolving phlegm,detoxifying,and fighting cancer can effectively improve the clinical symptoms of non-small cell lung cancer(Qi deficiency,phlegm obstruction,and toxin accumulation syndrome)patients,improve their quality of life,and is safe,reliable,and effective in reducing toxicity and increasing efficacy.

关 键 词：非小细胞肺癌 益气化痰解毒抗癌方 中医证候 气虚痰阻毒结证 生存质量 

分 类 号：R256.19[医药卫生—中医内科学]