微生物胞外多糖的生物合成途径  

The biosynthetic pathways of microbial exopolysaccharides

作　　者：张玥 张超[1] 刁梦奇 张岱州 刘飞[1,2] 张金华 ZHANG Yue;ZHANG Chao;DIAO Mengqi;ZHANG Daizhou;LIU Fei;ZHANG Jinhua(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Ji’nan 250355,China;Shandong Academy of Pharmaceutical Sciences,Ji’nan 250101,China)

机构地区：[1]山东中医药大学药学院,济南250355 [2]山东省药学科学院,济南250101

出　　处：《生命的化学》2024年第7期1270-1280,共11页Chemistry of Life

基　　金：济南市新高校20条资助项目(2021GXRC072);山东省科技型中小企业创新能力提升工程项目(2022TSGC1006);山东省重点研发计划(重大科技创新工程)项目(2021ZDSYS07)。

摘　　要：微生物胞外多糖(exopoly saccharides,EPS)是一类在医药、食品、化妆品等领域具有重要应用价值的高分子聚合物。随着合成生物技术在多糖合成领域的应用,EPS生物合成途径的研究受到更多关注。本文以透明质酸、黄原胶、结冷胶等多糖为代表,对目前EPS生物合成途径的研究进展进行了综述,重点介绍了其合成途径、关键酶和基因,并对EPS生物合成途径研究过程中存在的问题进行了讨论,旨在为EPS的生物合成研究提供参考。Microbial exopoly saccharides(EPS)are a class of high-molecular polymers with significant application value in the fields of medicine,food,cosmetics,et al.With the application of synthetic biology in the synthesis of EPS,research on their biosynthetic pathways has received increased attention.This paper provides a comprehensive review of the current research progress on the biosynthetic pathways of EPS,with a focus on representative examples such as hyaluronic acid,xanthan gum,and gellan gum.The review highlights the pathways,key enzymes,and genes involved in the biosynthesis of those EPS,and discusses the challenges of EPS biosynthetic pathways,aiming to provide valuable references for further studies on the biosynthesis of EPS.

关 键 词：微生物胞外多糖 生物合成途径 糖基转移酶 

分 类 号：Q939.9[生物学—微生物学]