ASIC1a介导类风湿关节炎软骨细胞损伤机制的研究进展  

Research progress on the mechanism of ASIC1a-mediated chondrocyte injury in rheumatoid arthritis

作　　者：钟玉梅 周海燕[2] 张敏[1] ZHONG Yumei;ZHOU Haiyan;ZHANG Min(Chengdu First People's Hospital/Chengdu Integrated TCM&Western Medicine Hospital Affiliated to Chengdu University of Traditional Chinese Medicine,Chengdu 610041,China;College of Acupuncture and Massage,Chengdu University of Traditional Chinese Medicine)

机构地区：[1]成都市第一人民医院/成都中医药大学附属中西医结合医院,610041 [2]成都中医药大学针灸推拿学院

出　　处：《天津医药》2024年第9期1004-1008,共5页Tianjin Medical Journal

基　　金：四川省自然科学基金青年项目(2023NSFSC1823);四川中医药文化协同发展研究中心一般项目(2022XT73);国家自然科学基金面上项目(81973959)。

摘　　要：类风湿关节炎(RA)是临床难治性自身免疫性疾病,骨破坏是RA中晚期的主要病理特征。酸敏感离子通道1a(ASIC1a)是细胞外H+激活的阳离子通道家族的一员,可将细胞外微环境的低pH信号传递至细胞内,激活下游信号通路,诱导一系列的病理变化。ASIC1a在RA发病中具有关键的作用,可促进关节炎症、滑膜增生、骨及关节软骨的破坏,在RA病理过程中具有重要意义。就ASIC1a的分子特性进行概述,并重点关注其改善RA软骨损伤的可能机制,为治疗RA提供新的思路。Rheumatoid arthritis(RA)is a clinically refractory autoimmune disease.The destruction of bone and articular cartilage is a key pathological feature in the middle and late stages of RA.Acid-sensing ion channel 1a(ASIC1a)is a member of extracellular H+activated cation channel family,which can transmit low pH signal from extracellular microenvironment into cells,activate downstream pathways and induce a series of pathological changes.New evidence shows that ASIC1a plays a key role in the pathogenesis of RA,promoting joint inflammation,synovial hyperplasia and the destruction of bone and articular cartilage,which is of great significance in the pathological process of disease.In this paper,the molecular characteristics of ASIC1a are briefly reviewed,and the possible mechanism of ASIC1a to improve cartilage injury of RA is emphasized,so as to provide new ideas for the treatment of RA.

关 键 词：关节炎 类风湿 软骨细胞 酸敏感离子通道 细胞凋亡 细胞外酸化 

分 类 号：R593.22[医药卫生—内科学]