两个全同胞叔叔与侄子之间的叔侄关系PI算法及应用  

The paternity index algorithm and its application of the uncle-nephew relationship between two full sibling uncles and one nephew

作　　者：张海涛[1,3] 王皓 尹秋丹 冀相云 刘淑文 Zhang Haitao;Wang Hao;Yin Qiudan;Ji Xiangyun;Liu Shuwen(Jilin Provincial Institute of Population and Life Science and Technology,Jilin Changchun 13004l;Jilin Maternal and Child Health Hospital,Jilin Changchun 13006l;Judicial Appraisal Center of Jilin Provincial Institute of Population and Life Science and Technology,Jilin Changchun 130041)

机构地区：[1]吉林省人口生命科学技术研究院,吉林长春130041 [2]吉林省妇幼保健院,吉林长春130061 [3]吉林省人口生科院司法鉴定中心,吉林长春130041

出　　处：《中国法医学杂志》2024年第4期399-403,406,共6页Chinese Journal of Forensic Medicine

摘　　要：目的 采用家系重建法建立两个已知全同胞叔叔与侄子之间的叔侄关系亲权指数算法。方法 按照孟德尔遗传规律对两个已知全同胞叔叔与侄子之间按照叔侄关系进行家系重建,以全同胞叔叔与侄子之间为叔侄关系和无关个体建立检验假设,运用Excel计算全同胞叔叔与侄子之间的叔侄关系亲权指数。结果 全同胞叔叔与侄子之间的99种基因分型组合,91种符合叔侄关系遗传规律,8种组合不符合叔侄关系遗传规律。不符合叔侄关系遗传规律的情形引入逐步突变模型。通过Excel可以计算全同胞叔叔与侄子之间的叔侄关系亲权指数。结论 两个已知全同胞叔叔参与的叔侄鉴定利用了辅助人的作用,得到的叔侄关系亲权指数高于两个全同胞叔叔单独与侄子的叔侄关系亲权指数,在帮助鉴定人得出倾向性明确的鉴定意见方面具有比较好的实用价值。Objective The family reconstruction method was used to establish paternity index algorithm for uncle-nephew relationships between two full sibling uncles and one nephew.Methods According to Mendelian genetic law,the family of two known full-sib uncles and one nephew were reconstructed according to the relationship between uncle and nephew,and the test hypothesis was established between two full sibling uncles and one nephew as the uncle-nephew relationship and unrelated individuals,and the paternity index of the uncle-nephew relationship between two full sibling uncles and one nephew was calculated by using Excel.Results Among the 99 genotypic combinations between two full sibling uncles and one nephew,91 of which were consistent with the genetic rules of uncle-nephew relationships,while 8 of which were not.a stepwise mutation model was introduced in the situations that do not conform to the genetic laws of uncle-nephew relationships.The paternity index of uncle-nephew relationship between two full sibling uncles and one nephew can be calculated using Excel.Conclusion The uncle-nephew testing involved by two full sibling uncles makes use of the role of the assistant,and the paternity index of the obtained uncle-nephew relationship is higher than that between two known full-siblings alone and their nephew,which has a good practical value in helping the appraiser to draw a clear appraisal opinion.

关 键 词：法医遗传学 全同胞叔叔 叔侄关系 亲权指数 家系重建 

分 类 号：D919.2[医药卫生—法医学]