免疫标记技术在死后经过时间推断中的研究进展  

Research progress of using immunolabeling techniques to estimate of postmortem interval

作　　者：张思航 郑吉龙[1] 李海鹏 张安杰 黄钰聪 牛勇 Zhang Sihang;Zheng Jilong;Li Haipeng;Zhang Anjie;Huang Yucong;Niu Yong(Criminal Investigation Police University of China,Shenyang 110035,China;Criminal Investigation Bureau of the Ministry of Public Security,Bejing 100006,China;Jinyuan Branch of Baotou Public Security Bureau,Baotou 041060,China)

机构地区：[1]中国刑事警察学院,辽宁沈阳110035 [2]公安部刑事侦查局,北京100006 [3]包头市公安局九原区分局,内蒙古包头041060

出　　处：《中国法医学杂志》2024年第4期473-478,共6页Chinese Journal of Forensic Medicine

基　　金：中国刑事警察学院研究生创新能力提升项目(2023YCYB55)。

摘　　要：死后经过时间的准确推断是法医病理学和刑事侦查领域的一项困难且极为关键的任务。近年来,物理、化学、微生物学、免疫学、昆虫学、分子生物学等学科方兴未艾,特殊染色、光谱、质谱、色谱、影像学等技术不断发展,用于死后经过时间推断的方法日益增多,其中免疫标记技术发挥了重要作用。本文系统地综述了国内外利用免疫标记技术推断死后经过时间的相关研究,包括免疫组化技术、免疫印迹技术、免疫荧光技术、放射免疫技术等,总结并分析这些技术在死后经过时间推断中的研究进展,以期为开拓法医病理学死后经过时间推断的研究思路,并能更好地将之应用于法医实践中提供参考。The accurate deduction of postmortem interval is a difficult and extremely critical task in the field of forensic pathology and criminal investigation.In recent years,physics,chemistry,microbiology,immunology,entomology,molecular biology and other disciplines have been on the rise,and special staining,spectroscopy,mass spectrometry,chromatography,radiographic and other techniques have been developed,and methods for postmortem interval inference are increasing,among which immunolabelling techniques have played an important role.In this paper,we systematically reviewed the domestic and foreign relevant studies on the postmortem interval inference using of immunolabelling techniques,including immunohistochemistry,immunoblotting,immunofluorescence,radioimmunoassay,etc.We summarized and analyzed the research progress on these techniques in postmortem interval inference,with the aim of exploring the ideas for the study of postmortem interval inference in forensic pathology,and provide reference for better applying them in forensic practice.

关 键 词：法医病理学 免疫标记技术 死后经过时间 综述 

分 类 号：D919.1[医药卫生—法医学]