Adipokinetic hormone signaling regulates adult dehydration resistance in the migratory locust  

作　　者：Xianliang Huang Dai Shi Kai Deng Shuzhen Jia Ding Ding Li Hou Bing Chen 

机构地区：[1]College of Life Sciences,Hebei University,Baoding 071002,China [2]Hebei Basic Science Center for Biotic Interaction,Hebei University,Baoding 071002,China [3]State Key Laboratory of Integrated Management of Pest Insects and Rodents,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Journal of Integrative Agriculture》2024年第9期3104-3117,共14页农业科学学报（英文版）

基　　金：supported by the National Key Research and Development Program of China(2022YFD1400503);the National Natural Science Foundation of China(32102208);the Hebei Natural Science Foundation,China(C2022201042,C2021201052 and C2023201075).

摘　　要：Drought events have become more severe under climate change,and this can pose a major threat to the survival of various organisms.The molecular mechanisms involved in dehydration resistance are not well known.Here,adults of the migratory locust,Locusta migratoria,were subjected to food-mediated dehydration,and adipokinetic hormone(AKH)signaling was found to play a key role in regulating dehydration resistance.Specifically,dehydration shortened the lifespan,increased the body weight loss,and reduced the water loss rate in adult locusts.Global transcriptome profiles revealed variations in tissue-specific gene expression between dehydration-resistant locusts and normal locusts.Importantly,dehydration selection and exposure induced prominent expression of AKH genes in the retrocerebral complex of adult locusts.Furthermore,individual knockdown of AKH1,AKH2,or AKH receptor(AKHR)accelerated water loss and shortened the lifespan of adult locusts under dehydration conditions,and trehalose supplementation ameliorated the negative effects caused by interference with AKH or AKHR.These findings demonstrated that AKH/AKHR signaling-dependent trehalose metabolism plays a crucial role in regulating locust dehydration resistance and thus provide novel insights into the regulatory mechanism underlying drought resistance.

关 键 词：adipokinetic hormone adipokinetic hormone receptor TREHALOSE dehydration resistance Locusta migratoria 

分 类 号：S433.2[农业科学—农业昆虫与害虫防治]