Highly sensitive detection of a long-COVID-related SNP in LZTFL1 allele with Pyrococcus furiosus Argonaute in point-of-care settings  

作　　者：Yixin Tang Miao Xu Bo Luo Yue Wang Yukang Chen Guangxi Yu Guang Yang Song Gao Pei Wang 

机构地区：[1]Jiangsu Key Laboratory of Marine Biological Resources and Environment,Co-Innovation Center of Jiangsu Marine Bio-industry Technology,Jiangsu Ocean University,Lianyungang 222005,China [2]School of Marine and Biological Engineering,Yancheng Teachers University,Yancheng 224007,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第7期1089-1092,共4页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the China Postdoctoral Science Foundation(No.2022M721665);the Research Program of the"521 Project"of Lianyungang City of China(No.LYG06521202133);the Lianyungang Key R&D Project(No.CG2305);the Lianyungang Postdoctoral Research Funding Program(No.LYG20220022);the Open-end Funds of Jiangsu Key Laboratory of Marine Bioresources and Environment(Nos.SH20221208 and SH20231212);the"Blue Project"of Jiangsu Higher Education Institutions of China;the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.

摘　　要：The leucine zipper transcription factor-like 1(LZTFL1)gene is active in respiratory and lung epithelia.Mutation of base G to A at the rs17713054 locus on the LZTFL1 allele causes an increase in the expression of the gene,leading to an increase in viral load after SARS-CoV-2 infection[1].This mutation significantly increases the risk of developing severe cases and long-term symptoms of COVID-19(long-COVID)[2].

关 键 词：LZTFL1 ALLELE LUNG 

分 类 号：R563.1[医药卫生—呼吸系统]