单向导湿抗菌敷料的制备及性能研究  

Preparation and property study of antibacterial dressings with unidirectional moisture transmissibility

作　　者：张赛 董硕 董东东 葛效成 陈振远 王蕊鑫 孙召彬 杨帆[1] Zhang Sai;DONG Shuo;DONG Dongdong;GE Xiaocheng;CHEN Zhenyuan;WANG Ruixin;SUN Zhaobin;YANG Fan(Dezhou University,Dezhou,253023,China;Linyi Aobo Textile Thread Co.,Ltd.,Linyi,276000,China;Zhongyuan University of Technology,Zhengzhou,451191,China)

机构地区：[1]德州学院,山东德州253023 [2]临沂市奥博纺织制线有限公司,山东临沂276000 [3]中原工学院,河南郑州451191

出　　处：《棉纺织技术》2024年第9期34-40,共7页Cotton Textile Technology

基　　金：国家自然科学基金项目(22104010);山东省自然科学基金项目(ZR2021QB141)。

摘　　要：为了获得具备单向导湿功能的抗菌敷料,利用静电纺丝技术成功制备了聚乳酸/纳米氧化锌-聚乳酸/壳聚糖(PLA/ZnO-PLA/CS)双层结构纳米纤维膜和聚乳酸/纳米氧化锌-聚乳酸/壳聚糖-聚乙烯醇/透明质酸(PLA/ZnO-PLA/CS-PVA/HyA)三层结构纳米纤维膜。对双层结构和三层结构纳米纤维膜敷料的微观形貌、化学基团、墨滴扩散、吸水性、亲水性、抗菌性及生物安全性进行了测试分析。结果表明:从PLA/ZnO内层、PLA/CS中间层到PVA/HyA外层,纳米纤维的直径逐渐减小,孔径逐渐减小,孔隙率逐渐升高;具有梯度结构的三层纳米纤维膜敷料亲水性最佳,且PLA/ZnO内层可形成明显抑菌圈,具有良好抗菌性;三层梯度结构敷料成分不会影响细胞增殖,无细胞毒性;PLA/CS层和PVA/HyA层形成梯度引流作用,具有优良的单向导湿功能,可将伤口处积液引流到敷料外层。认为:纺丝时间为3 h的三层梯度纳米纤维膜在导湿、抗菌方面性能突出,对细胞无毒性,适用于伤口敷料相关产品的开发。In order to obtain the wound dressings with unidirectional moisture transmissibility and antibacterial property,polylactic acid/nano-zinc oxide-PLA/chitosan(PLA/ZnO-PLA/CS)nanofiber membrane with doublelayered structure and polylactic acid/nano-zinc polylactic acid/chitosan polyvinyl alcohol/hyaluronic acid(PLA/ZnO-PLA/CS-PVA/HyA)nanofiber membrane with tri-layered structure were successfully prepared by electrospinning technology.The micro-morphology,chemical group,ink diffusion,water absorption,hydrophilicity,antibacterial property and biosecurity of bi-layered and tri-layered dressings were tested and analyzed.The results showed that the fiber diameter of nanofibers were gradually decreased,pore diameter was gradually decreased and the porosity was gradually increased from PLA/ZnO inlayer,PLA/CS interlayer to PVA/HyA outer layer.The trilayered nanofiber membrane with gradient structure had the best hydrophilicity for the antibacterial dressings.Antibacterial zone could be obviously formed in the PLA/ZnO inner layer with better antibacterial property.Cell proliferation would not be affected by the tri-layered gradient structural dressing ingredient and it was non cytotoxicity.PLA/CS layer and PVA/HyA layer formed a gradient drainage structure with excellent unidirectional moisture transmissibility,which could drain the wound effusion to the outer layer of the dressing.It is considered that tri-layered gradient nanofibrous membranes with 3 h spinning has excellent performances in moisture transmissibility and antibacterial property.It is out of cytotoxicity and suitable for the development of wound dressing related products.

关 键 词：创伤敷料 梯度结构 单向导湿 抗菌性能 纳米纤维 

分 类 号：TS174.8[轻工技术与工程—纺织材料与纺织品设计]