基于数据挖掘的中药治疗小儿湿疹的用药规律  被引量:1

Typical Usage of Traditional Chinese Medicine in Treatment of Infantile Eczema Based on Data Mining

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作  者:李婕 张泽 王永强 孙华燕[2] LI Jie;ZHANG Ze;WANG Yong-qiang;SUN Hua-yan(Hospital of the First Mobile Corps of the Chinese People's Armed Police Force,Dingzhou 073000,China;Medical Supplies Center of PLA General Hospital,Beijing 100853,China)

机构地区:[1]武警第一机动总队医院,河北定州1073000 [2]解放军总医院医疗保障中心,北京2100853

出  处:《解放军药学学报》2024年第4期330-333,共4页Pharmaceutical Journal of Chinese People's Liberation Army

摘  要:目的通过数据挖掘的方法探讨中药方剂治疗小儿湿疹的专利复方组合规律。方法检索中国专利全文数据库(知网版)中的专利,收集自建库至2023年6月11日治疗小儿湿疹的中药组方专利,对所得药物组合及其性味归经用频数分析、聚类分析、关联规则分析评估。结果筛选共得专利药物组合85个,373味中药饮片,含高频中药饮片31味。功效统计以清热解毒、清热燥湿以及攻毒杀虫止痒为主,药性以寒、温、平为主,药味以苦、甘、辛为主,归经多为肝、胃、脾经。分析得到药物关联规则9条;聚类分析药物组合6类。结论小儿湿疹急性期时以清热解毒、清热燥湿为主,后期以补气、补血为主,以达到急则治标,缓则治本的治疗原则,为临床遣方用药提供参考。Objective To explore the way in which patent compound prescriptions of traditional Chinese medicine(TCM)for infantile eczema(IE)are used based on data mining.Methods Related patents were searched for from the"China Patent Full-text Database(Zhiwang Net)".Patent compound prescriptions for IE that were published from the inception of the database to June 11,2023 were retrieved.The properties,tastes,and sites of action of the these drug combinations were assessed using frequency analysis,cluster analysis,and association rule analysis.Results After screening,a total of 85 patent TCM combinations and 373 types of decoction pieces(including 31 types of high-frequency ones)were included in the study.The efficacy statistics focused on such properties as heat-clearing and detoxifying,heat-clearing and dampness-removing,toxin-attacking,insect-killing and itching-relieving effects.The medicinal properties were mostly cold,warm and plain while the medicinal tastes were usually bitter,sweet and pungent.The sites of action revolved around the liver,stomach,and spleen.As many as 9 core combinations were obtained.Cluster analysis involved six drug combinations.Conclusion Treatment should be oriented to heat-clearance,detoxification and dampness-removal in the acute stage of IE,and to replenishment of Qi and blood in the later stage.For acute cases,symptoms should be alleviated and for mild cases,the root cause of disease should be addressed.

关 键 词:小儿湿疹 专利组方 中医药 数据挖掘 用药规律 

分 类 号:R969[医药卫生—药理学]

 

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