现代与传承:STING激动剂的双重视角  

Modernity and heritage:a dual perspective on STING agonists

作　　者：赵凤 李雪 王蕊 王玉明[1] 李云飞 ZHAO Feng;LI Xue;WANG Rui;WANG Yuming;LI Yunfei(College of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中药学院,天津301617

出　　处：《天津中医药大学学报》2024年第8期762-768,共7页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82374300)。

摘　　要：cGAS-STING信号通路是免疫系统中的关键调节因子,对肿瘤免疫治疗具有重要的研究和应用前景。该信号通路激活STING蛋白后,能够促进I型干扰素(IFN-I)的产生,并进一步影响树突细胞的成熟,增强T淋巴细胞和自然杀伤(NK)细胞的攻击力,从而连接先天免疫和适应性免疫反应。文章重点回顾了化学类STING激动剂以及中药成分对cGAS-STING信号通路的调节作用。这些研究不仅揭示了STING激动剂的分子机制,而且为开发新型免疫调节剂提供了理论基础。此外,文章还探讨了中药成分与现代药物设计的结合潜力,为未来免疫治疗的研究提供了新的视角和策略。The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway is a pivotal regulator within the immune system and holds significant potential for research and application in cancer immunotherapy.Upon activation of the STING protein by this pathway,it promotes the production of Type I interferons,which subsequently affects the maturation of dendritic cells and enhances the cytotoxic capabilities of T lymphocytes and natural killer cells,thereby bridging innate and adaptive immune responses.This review focuses on the regulatory effects of chemical STING agonists and the modulation of the cGAS-STING signaling pathway by components derived from traditional Chinese medicine(TCM).These studies not only elucidate the molecular mechanisms of STING agonists but also provide a theoretical foundation for the development of novel immunomodulatory agents.Furthermore,this review discusses the potential integration of TCM components with modern drug design,offering new perspectives and strategies for future research in immunotherapy.

关 键 词：STING激动剂 中药类STING激动剂 cGAS-STING信号通路 

分 类 号：R2-03[医药卫生—中医学]