麝香通心滴丸对冠状动脉慢血流患者冠脉血流储备的影响  

Effect of Shexiang Tongxin Dripping Pills on coronary flow reserve in patients with coronary slow flow phenomenon

作　　者：韩勇 铁春苗 沈男男 HAN Yong;TIE Chunmiao;SHEN Nannan(Department of Pharmacy,Affiliated Hospital of Shaoxing University,Shaoxing,Zhejiang 312000,China;不详)

机构地区：[1]绍兴文理学院附属医院药剂科,浙江绍兴312000 [2]绍兴文理学院附属医院心血管内科

出　　处：《中华全科医学》2024年第9期1530-1532,1627,共4页Chinese Journal of General Practice

基　　金：浙江省医学会临床医学专项资金项目(2023ZYC-A55);浙江省教育厅一般科研项目(Y202249053)。

摘　　要：目的观察麝香通心滴丸治疗冠状动脉慢血流的临床疗效,探究麝香通心滴丸对患者冠脉血流储备(CFR)的改善作用。方法将绍兴文理学院附属医院2023年1—12月收治的88例冠状动脉慢血流患者按随机数字表法分为对照组(44例)、观察组(44例),对照组予常规治疗,观察组合用麝香通心滴丸治疗。比较2组治疗前后凝血功能、校正的TIMI血流帧数(CTFC)、冠脉血流储备、炎性因子以及不良反应。结果治疗4周后,观察组凝血酶时间[(22.56±1.31)s]、凝血酶原时间[(13.41±1.16)s]、活化部分凝血活酶时间[(42.80±3.83)s]均大于对照组[(19.53±1.94)s、(12.19±0.99)s、(38.74±4.17)s],差异有统计学意义(P<0.05);观察组纤维蛋白原[(2.03±0.43)g/L]低于对照组[(2.38±0.49)g/L],差异有统计学意义(F=56.916,P<0.05)。观察组CTFC、冠状动脉血流峰值速度水平低于对照组,观察组最大冠状动脉血流峰值速度、CFR水平高于对照组(P<0.05);观察组高敏C反应蛋白、白细胞介素-6低于对照组(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论冠状动脉慢血流患者应用麝香通心滴丸治疗有较好的效果,对患者凝血功能、炎性因子有明显的改善作用,还能增加冠脉血流储备,不良反应少。Objective To investigate the clinical efficacy of Shexiang Tongxin Dripping Pills in treating coronary slow flow phenomenon(CSFP),and to explore its effect on improving coronary flow reserve(CFR)in patients.MethodsEighty-eight patients with coronary slow flow who were admitted to Affiliated Hospital of Shaoxing University from January to December 2023 were selected and randomly divided into the control group(n=44)and the observation group(n=44).The control group was given conventional treatment,and the observation group was treated with Shexiang Tongxin Dripping Pills in addition to the conventional treatment.The blood coagulation function,corrected TIMI frame count(CTFC),CFR and inflammatory factors before and after treatment were compared,as well as the adverse reactions after medication.ResultsAfter 4 weeks of treatment,the thrombin time(TT)in the observation group[(22.56±1.31)s]was higher than that in the control group[(19.53±1.94)s],and the difference was statistically significant(P<0.05).Similarly,the prothrombin time(PT)in the observation group[(13.41±1.16)s]was higher than that in the control group[(12.19±0.99)s]with a statistically significant difference as well(P<0.05).Additionally,the activated partial thromboplastin time(APTT)in the observation group[(42.80±3.83)s]was also higher compared to APTT[(38.74±4.17)s]in the control group(P<0.05).On contrary,fibrinogen(Fib)in the observation group[(2.03±0.43)g/L]was lower than the control group[(2.38±0.49)g/L]with statistically significant difference(F=56.916,P<0.05).The levels of CTFC and basal flow velocity(BFV)in the observation group were lower than those in the control group,while the maximal flow velocity(MFV)and CFR levels were higher than those in the control group(P<0.05).The levels of hypersensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in adverse reactions between two groups(P>0.05).Conclusion Shexiang Ton

关 键 词：冠状动脉慢血流 麝香通心滴丸 凝血功能 冠脉血流储备 

分 类 号：R543.3[医药卫生—心血管疾病]