罗沙司他致甲状腺功能减退1例  

Hypothyroidism caused by roxadustat:a case report

作　　者：杨云娇[1] 王曦[2] 闫雪莲[3] 谢海雁 YANG Yunjiao;WANG Xi;YAN Xuelian;XIE Haiyan(Department of Rheumatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100032,China;不详)

机构地区：[1]中国医学科学院北京协和医院风湿免疫科,北京100032 [2]中国医学科学院北京协和医院内分泌科 [3]中国医学科学院北京协和医院药剂科,北京100730 [4]中国医学科学院,北京协和医院保健医疗部

出　　处：《中华全科医学》2024年第9期1628-1630,共3页Chinese Journal of General Practice

基　　金：北京协和医院沉淀科研经费整合委托项目基金(ZC201904826)。

摘　　要：本文报道了1例缺氧诱导因子脯氨酰羟化酶抑制剂罗沙司他治疗肾性贫血导致的甲状腺功能减退。患者男性,86岁,因“诊断慢性肾功能不全10年,少言、进食减少3周”就诊。用药4个月后出现甲状腺功能减退的症状及实验室检查异常。停用罗沙司他1周后甲状腺功能逐渐恢复正常。提示对接受罗沙司他治疗的患者,用药后应定期监测甲状腺功能,必要时停药或使用甲状腺激素替代治疗。This article reports a case of hypothyroidism caused by roxadustat,a prolyl-hydroxylase inhibitor,used to treat renal anemia.An 86-year-old male with a 10-year history of chronic renal insufficiency with reduced speech and food intake for 3 weeks.After 4 months of medication,symptoms of hypothyroidism and abnormal laboratory tests appeared.After discontinuing roxadustat for one week,his thyroid function gradually normalized.For patients receiving roxadustat treatment,regular thyroid function monitoring is essential,and discontinuation or thyroid hormone replacement therapy should be considered if necessary.

关 键 词：肾性贫血 罗沙司他 甲状腺功能 

分 类 号：R581.2[医药卫生—内分泌] R969.3[医药卫生—内科学]