温度响应型水凝胶的生物应用研究  

Biological Application of Temperature Responsive Hydrogels

作　　者：孙天赐 陈祥顺 许逊 王俊[2] 宁仁德[2] 李庆[3] 何涛 SUN Tian-ci;CHEN Xiang-shun;XU Xun;WANG Jun;NING Ren-de;LI Qing;HE Tao(School of Chemistry and Chemical Engineering,Hefei University of Technology,Hefei 230009,China;Anhui Medical University,Hefei 230009,China;University of Science and Technology of China,Hefei 230022,China)

机构地区：[1]合肥工业大学化学与化工学院,安徽合肥230009 [2]安徽医科大学,安徽合肥230009 [3]中国科学技术大学,安徽合肥230022

出　　处：《安徽化工》2024年第4期15-18,22,共5页Anhui Chemical Industry

摘　　要：温度响应型水凝胶是目前研究最广泛的一种智能响应型水凝胶,在低温下呈现溶液状态,可以被注射;注射到体内后,体温的刺激使处于溶液状态的水凝胶材料原位凝胶化,覆盖在皮肤/组织表面。主要阐释了温度响应型水凝胶的温度响应机理及其在生物领域中的应用,结合国内外相关研究,讨论了近年来温度响应型水凝胶向临床转化存在的问题及未来研究的方向。Temperature responsive hydrogel is one of the most widely studied intelligent responsive hydrogels,which can be injected in solution at low temperature.After injection into the body,the stimulation of body temperature causes the hydrogel material in solution to gel in situ,covering the skin/tissue surface.This review mainly explains the temperature response mechanism of temperature-responsive hydrogels and their applications in the biological field.Combined with relevant researches at home and abroad,the problems existing in the clinical transformation of temperature-responsive hydrogels in recent years and the future research direction are discussed.

关 键 词：温度响应型水凝胶 原位凝胶化 生物应用 临床转化 

分 类 号：O63[理学—高分子化学]