3-溴吡啶连续化合成工艺研究  

Study on the Continuous Synthesis of 3-Bromopyridine

作　　者：谷顺明 刘国良 张正涛 金文娟 温兰兰 GU Shun-ming;LIU Guo-liang;ZHANG Zheng-tao;JIN Wen-juan;WEN Lan-lan(Anhui Costar Biochemical Co.Ltd.,Maanshan 243100,China)

机构地区：[1]安徽国星生物化学有限公司,安徽马鞍山243100

出　　处：《安徽化工》2024年第4期65-68,共4页Anhui Chemical Industry

摘　　要：采用分段式管式反应器连续化合成3-溴吡啶,当吡啶、氢溴酸和双氧水按摩尔比为1∶3∶1.2,一段管式反应器温度为50℃,停留时间为5 min,二段管式反应器温度为90℃,停留时间为20 min时,吡啶转化率达到99.2%,反应收率达到80.6%。采用负压精馏提纯,3-溴吡啶含量达到98.5%以上。合成与分离过程节能、高效,适合工业化生产。3-Bromopyridine was synthesized continuously in a two-stage tubular reactor.The molar ratio of pyridine,hydrobromic acid and hydrogen peroxide was 1∶3∶1.2.The temperature of the first-stage tubular reactor was 50℃and the residence time was 5 min.The temperature of the second-stage tubular reactor was 90℃and the residence time was 20 min.The conversion rate of pyridine reached 99.2%and the reaction yield was 80.6%.The content of 3-bromopyridine reached 98.5%by negative pressure distillation.The process of synthesis and separation is energy saving and high efficiency,

关 键 词：管式反应器 连续化合成 3-溴吡啶 负压精馏 

分 类 号：TQ253[化学工程—有机化工]