6-溴喹啉分析检测方法的研究  

Study on 6-Bromoquinoline Analysis and Detection Method

作　　者：焦剑 JIAO Jian(Anhui Yingtemei Technology Co.Ltd.,Bengbu 233000,China)

机构地区：[1]安徽英特美科技有限公司,安徽蚌埠233000

出　　处：《安徽化工》2024年第4期128-130,共3页Anhui Chemical Industry

摘　　要：建立6-溴喹啉高效液相色谱检测方法,优先选用C18柱作为分离色谱柱;选择三氟乙酸乙腈溶液及三氟乙酸水溶液作为流动相,并以梯度洗脱的方式进行;检测器为紫外检测器,检测波长为240 nm。利用卡尔·费休水分测定仪研究6-溴喹啉水分含量。最后对检测方法的准确度和精密度进行了验证研究。Establish a high-performance liquid chromatography detection method for 6-bromoquinoline,prioritizing C18 column as the separation column.Select trifluoroacetic acid acetonitrile solution and trifluoroacetic acid aqueous solution as mobile phases,and perform gradient elution.The detector is an ultraviolet detector with a detection wavelength of 240 nm.Using a Karl Fischer moisture analyzer,study the moisture content of 6-bromoquinoline.Finally,a validation study was conducted on the accuracy and precision of the detection method.

关 键 词：液相色谱 喹啉类化合物 药物中间体 有机合成 卡尔费休 

分 类 号：O657[理学—分析化学]