Mediating function of heart failure in the causal relationship between diastolic blood pressure and hypertensive renal disease with renal failure:a mediated Mendelian randomization study  

作　　者：Lei Pang Zi-Jun Ding Hong-Qiang Chai Fei Li Ming Wu Wei-Bing Shuang 

机构地区：[1]Department of Urology,The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital),Taiyuan,Shanxi 030012,China [2]First Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi 030012,China [3]Department of Neonatology,Shanxi Children’s Hospital,Taiyuan,Shanxi 030013,China [4]Department of Urology,The First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030012,China

出　　处：《Frontiers of Nursing》2024年第3期285-294,共10页护理前沿（英文）

基　　金：supported by the scientific research project of Shanxi Provincial Health Commission(No.2022073)。

摘　　要：Objective:To study the causality relationship between diastolic blood pressure(DBP)and hypertensive renal disease with renal failure(HRDRF)and the mediating role of hear t failure(HF)in the causality relationship by network Mendelian randomization(MR).Methods:Genome-wide analysis of DBP,HRDRF,and HF was downloaded from the public database(Genome-Wide Analysis Study[GWAS])and was used to analyze the results and to conduct mediated MR analysis.Results:Analysis showed that DBP was positively correlated with HRDRF(OR=1.0002,95%CI:1.0001–1.0003,P=1.8076e-05)and DBP was positively correlated with HF(OR=1.0295,95%CI:1.0221–1.0370,P=2.5292e-15).HF and HRDRF had a positive causal effect(OR=1.0001,95%CI:1.0000–1.0001,P=0.0152).Mediation analysis showed that the contribution ratio of HF to the combined effect of DBP and HRDRF was 24.69%.Conclusions:DBP can increase the risk of renal disease with renal failure,and HF may play an impor tant role in mediating this causal relationship.

关 键 词：atherosclerotic heart disease diastolic blood pressure heart arrhythmia heart failure hypertensive renal disease with renal failure Mendelian randomization 

分 类 号：R473.5[医药卫生—护理学]