杀鲑气单胞菌对亚东鲑血液免疫指标的影响  

Effects of Aeromonas Salmonicida on Blood Immune Indexes of Salmo Trutta

作　　者：雷宽宽 周建设 王万良 王壮壮 周莉 王子位 李明[1] LEI Kuankuan;ZHOU Jianshe;WANG Wanliang;WANG Zhuangzhuang;ZHOU Li;WANG Ziwei;LI Ming(College of Animal Science and Technology,Henan Agricultural University,Henan Zhengzhou 450002,China;Institute of Fisheries Science,Xizang Autonomous Region Academy of Agricultural and Animal Husbandry Sciences,Tibet Lhasa 850032,China;Xizang Indigenous Fish Breeding and Utilization Engineering Research Center,Tibet Lhasa 850032,China;Key Laboratory of Fishery and Germplasm Resources Utilization of Xizang Autonomous Region,Tibet Lhasa 850032,China;Henan University of Animal Husbandry and Economy,Henan Zhengzhou 450046,China.)

机构地区：[1]河南农业大学动物科技学院,河南郑州450002 [2]西藏自治区农牧科学院水产科学研究所,西藏拉萨850032 [3]西藏土著鱼类繁育与利用工程研究中心,西藏拉萨850032 [4]西藏自治区渔业与种质资源利用重点实验室,西藏拉萨850032 [5]河南牧业经济学院,河南郑州450046

出　　处：《西藏农业科技》2024年第3期5-10,共6页Tibet Journal of Agricultural Sciences

基　　金：西藏自治区科技计划项目(XZ202101ZY0003N);国家特色淡水鱼产业技术体系项目(CARS-46)。

摘　　要：为预防杀鲑气单胞菌在亚东鲑养殖过程中造成的危害,以杀鲑气单胞菌为研究对象,通过感染亚东鲑,检测其对亚东鲑免疫指标的影响。结果表明:GR组亚东鲑血清中白细胞介素1β(IL-1β)含量随感染时间增加显著性上升(p<0.05),免疫球蛋白A(Ig A)含量也呈现上升趋势,而转化生长因子β1(TGF-β1)含量则表现出相反趋势,其含量显著性降低(p<0.05);GR组血常规指标中除血小板分布宽度(PDW)外,其它指标均在48h呈现显著性降低(p<0.05),除红细胞压积(HCT)外,其它指标均在96 h呈现上升趋势。杀鲑气单胞菌能够引发亚东鲑炎症反应,导致IL-1β和IgA含量升高,TGF-β1含量降低;在感染亚东鲑48 h能够破坏其免疫系统,导致白细胞、红细胞及血小板等数目显著性减少。To prevent the harm caused by Aeromonas salmonicida in the cultivation of Salmo trutta,this study took Aeromonas salmonicida as the research object,and detected its effect on the immune indexes of Salmo trutta by infecting Salmo trutta.The results showed that the serum content of interleukin 1β(IL-1β)in the GR group increased significantly with the duration of infection(p<0.05).The content of immunoglobulin A(IgA)also showed an upward trend,while the content of transforming growth factorβ1(TGF-β1)showed an opposite trend and decreased significantly(p<0.05).In the GR group,all indexes decreased significantly at 48h(p<0.05)except platelet distribution width(PDW)and all indexes showed an upward trend at 96h except hematocrit(HCT).Aeromonas salmonicida could trigger an inflammatory response in Salmo trutta,resulting in increased IL-1βand IgA levels and decreased TGF-β1 levels.After 48h of infection,the immune system of Salmo trutta was compromised,leading to a significant decrease in the number of white blood cells,red blood cells,and platelets.

关 键 词：亚东鲑 杀鲑气单胞菌 血清免疫指标 血常规 

分 类 号：S917.4[农业科学—水产科学]