中国肾脏移植受者侵袭性镰刀菌病临床诊疗指南  

Guidelines for clinical diagnosis and treatment of invasive fusaridiosis in kidney transplant recipients in China

作　　者：中华医学会器官移植学分会 冯钢[2] 郭丽平 赵杰[2] 门同义 王祥慧[4] Branch of Organ Transplantation of Chinese Medical Association;Men Tongyi;Wang Xianghui;无(不详;Tianjin First Central Hospital,Tianjin 300192,China)

机构地区：[1]不详 [2]天津市第一中心医院,天津300192 [3]内蒙古医科大学附属医院 [4]上海交通大学医学院附属瑞金医院

出　　处：《器官移植》2024年第5期737-744,共8页Organ Transplantation

基　　金：天津市科技计划项目(21JCYBJC01010)。

摘　　要：镰刀菌是临床上最常见的霉菌,在免疫机能正常的宿主中引起浅部感染,如角膜炎,在免疫功能低下的个体中可引起严重的播散性感染(通常表现为真菌血症)。对镰刀菌病的预防及治疗是关系肾脏移植受者长期存活的重要环节。为了推动肾脏移植受者侵袭性镰刀菌病临床诊疗的规范化,由中华医学会器官移植学分会发起制定了《中国肾脏移植受者侵袭性镰刀菌病临床诊疗指南》。本指南使用2009版牛津大学循证医学中心的证据分级与推荐强度标准对每个临床问题的证据质量和推荐强度进行分级。针对肾脏移植侵袭性镰刀菌病临床诊疗相关的13个临床问题,提出了符合我国临床诊疗实践的14条推荐意见,旨在推进对肾脏移植术后侵袭性镰刀菌病诊疗方案的规范化,以促进和改善肾脏移植受者和移植肾长期存活。Fusarium is the most common mold in clinical practice,which may cause superficial infection in hosts with normal immune function,such as keratitis and severe disseminated infection(primarily manifested as fungemia)in individuals with poor immune function.Prevention and treatment of fusaridiosis are associated with long-term survival of kidney transplant recipients.To promote the standardization of clinical diagnosis and treatment of invasive fusaridiosis in kidney transplant recipients,Branch of Organ Transplantation of Chinese Medical Association initiated and formulated“Guidelines for Clinical Diagnosis and Treatment of Invasive Fusaridiosis in Kidney Transplant Recipients in China”.In this guideline,the levels of evidence and strengths of recommendation for each clinical problem were classified using Oxford Center for Evidence-based Medicine of 2009.Regarding 13 clinical problems related to clinical diagnosis and treatment of invasive fusaridiosis after kidney transplantation,14 recommendations were proposed in accordance with clinical diagnosis and treatment practice in China,aiming to promote the standardization of diagnosis and treatment of invasive fusaridiosis after kidney transplantation and improve long-term survival of both recipients and renal allografts after kidney transplantation.

关 键 词：肾脏移植 镰刀菌 感染 侵袭性 播散性 伏立康唑 泊沙康唑 两性霉素B 

分 类 号：R617[医药卫生—外科学] R379[医药卫生—临床医学]