慢性细菌性前列腺炎病原菌及血清免疫球蛋白和VCAM-1与MCP-1水平  

Pathogenic bacteria and levels of serum immunoglobulins,VCAM-1 and MCP-1 in patients with chronic bacterial prostatitis

作　　者：刘安全[1] 陈挺[1] LIU An-quan;CHEN Ting(Lishui Central Hospital,Lishui,Zhejiang323000,China)

机构地区：[1]丽水市中心医院泌尿外科,浙江丽水323000

出　　处：《中华医院感染学杂志》2024年第16期2481-2486,共6页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生科技计划基金资助项目(2023KY1364)。

摘　　要：目的探究慢性细菌性前列腺炎患者病原菌特征及与血清免疫球蛋白和血管细胞黏附分子-1(VCAM-1)、单核细胞趋化蛋白-1(MCP-1)水平变化的关系。方法以2021年6月-2023年6月丽水市中心医院收治的118例慢性细菌性前列腺炎患者(感染组)及30名健康体检者(对照组)为研究对象,对感染组患者主要致病菌特征及耐药性进行分析;应用西门子BNII特定蛋白分析仪检测受试者血清免疫球蛋白(Ig)A、IgG、IgM水平,采用酶联免疫吸附法检测血清VCAM-1水平,采用放射免疫法检测患者血清MCP-1水平;根据美国国立卫生研究院慢性前列腺炎症状积分指数得分将感染组患者分为轻度组、中度组及重度组,分析血清免疫球蛋白和VCAM-1、MCP-1水平与病情严重程度的相关性;感染组患者均给予针对性干预,根据治疗疗效将其分为有效组及无效组,分析血清免疫球蛋白和VCAM-1、MCP-1水平对慢性细菌性前列腺炎治疗疗效的评估价值。结果溶血葡萄球菌、表皮葡萄球菌、金黄色葡萄球菌为主要革兰阳性菌,大肠埃希菌为主要革兰阴性菌;感染组血清IgA、IgG、IgM水平及VCAM-1、MCP-1水平高于对照组(P<0.05);慢性细菌性前列腺炎患者血清IgA、IgG、IgM水平及VCAM-1、MCP-1水平随病情的加重呈升高趋势(P<0.05);重度组血清IgA、IgG、IgM水平及VCAM-1、MCP-1水平高于中度组、轻度组,且中度组高于轻度组(P<0.05);慢性细菌性前列腺炎患者血清IgA、IgG、IgM水平及VCAM-1、MCP-1水平与病情严重程度呈正相关(P<0.05);有效组治疗后血清IgA、IgG、IgM水平及VCAM-1、MCP-1水平低于无效组(P<0.05);血清免疫球蛋白和VCAM-1、MCP-1水平联合检测评估慢性细菌性前列腺炎患者治疗疗效的曲线下面积(AUC)大于各指标单独检测(P<0.05)。结论慢性细菌性前列腺炎的主要致病菌为溶血葡萄球菌、表皮葡萄球菌,其对青霉素、苯唑西林等耐药性较高,且患者血清免疫�OBJECTIVE To explore the characteristics of pathogenic bacteria in patients with chronic bacterial prostatitis and their relationship with changes of serum immunoglobulins,vascular cell adhesion molecule-1(VCAM-1)and monocyte chemoattractant protein-1(MCP-1)levels.METHODS A total of 118 patients with chronic bacterial prostatitis(as the infection group)and 3o healthy volunteers under physical examination(as the control group)in Lishui Central Hospital from Jun 2021 to Jun 2023 were recruited.The characteristics and drug resistance of the main pathogenic bacteria in the infection group were analyzed.Siemens BNII specific protein analyzer was used to detect the levels of serum immunoglobulin(Ig)A,IgG and IgM,and enzyme linked immunosorbent assay was performed to detect serum level of VCAM-1.Serum MCP-1 level was detected by radioimmunoassay.According to the National Institutes of Health chronic prostatitis symptom index,the patients in the infection group were divided into the mild group,moderate group and severe group.The correlation between serum immunoglobulins,VCAM-1 and MCP-1 levels and disease severity was analyzed.Patients in the infection group were given targeted intervention,and they were classified into the effective group and ineffective group according to the therapeutic efficacy.The value of serum immunoglobulins,VCAM-1 and MCP-1 levels on the evaluation of therapeutic efficacy of chronic bacterial prostatitis was analyzed.RESULTS Staphylococcus haemolyticus,Staphylococcus epidermidis and Staphylococcus aureus were the main gram-positive pathogenic bacteria,and Escherichia coli was the main gram-negative pathogenic bacteria.Serum levels of IgA,IgG,IgM,VCAM-1 and MCP-1 in the infection group were higher than those in the control group(P<o.05).The serum levels of IgA,IgG,IgM,VCAM-1 and MCP-1 in patients with chronic bacterial prostatitis were increased with the aggravation of disease condition(P<0.05).The levels of serum IgA,IgG,IgM,VCAM-1 and MCP-1 were higher in the severe group than those in the mode

关 键 词：慢性细菌性前列腺炎 病原菌 免疫球蛋白 血管细胞黏附分子-1 单核细胞趋化蛋白-1 

分 类 号：R697.33[医药卫生—泌尿科学]