基于数据挖掘分析慢性肾脏病脾肾气虚兼湿瘀证的药量规律  

Analysis of medication and dosage pattern of chronic kidney disease with spleen and kidney qi deficiency combined with dampness and stasis based on data mining

作　　者：李劲波 梁谋[1] 孙季菡 LI Jingbo;LIANG Mou;SUN Jihan(Department of Nephrology,Shunde Hospital,Guangzhou University of Chinese Medicine,Guangdong Province,Foshan 528300,China)

机构地区：[1]广州中医药大学顺德医院肾内科,广东佛山528300

出　　处：《中国医药导报》2024年第23期164-169,175,共7页China Medical Herald

基　　金：广州省佛山市卫生健康局医学科研项目(20210257)。

摘　　要：目的基于数据挖掘探讨中医药治疗慢性肾脏病(非透析)脾肾气虚兼湿瘀证的临床用药及其剂量规律。方法检索中国知网、万方数据知识服务平台、维普网自2004年1月至2024年2月收录的相关文献,将合格文献中的处方用药录入,建立对应的数据库。运用WPS Excel、SPSS Modeler 18.0、SPSS Statistics 27.0软件进行中药频次、性味归经及功效类别统计、关联规则和系统聚类分析。结果纳入符合标准的文献53篇,包含53首处方,127种中药,总频次为715次,高频中药有21味,高频中药剂量范围为10~30 g。使用频率较高的中药及剂量依次为黄芪30 g、茯苓15 g、大黄10 g等。药性以温、寒、平多见,药味以甘、苦、辛为主,归经多为肝、脾、肾经。药物功效类别统计获得16类。关联规则分析获得核心药对14组、核心药量对13组。聚类分析得出10个聚类方。结论本研究一定程度上揭示了中医药治疗慢性肾脏病(非透析)脾肾气虚兼湿瘀证的用药及其剂量规律,可为临床药量选择提供一定参考。Objective To explore the clinical medication and its dosage pattern based on data mining in traditional Chinese medicine for the treatment of chronic kidney disease(non-dialysis)with spleen and kidney qi deficiency combined with dampness and stasis.Methods The relevant public literature were collected by CNKI,Wanfang Data,and VIP from January 2004 to February 2024,prescription drugs in qualified literature were entered,and the corresponding database was established.WPS Excel,SPSS Modeler 18.0,and SPSS Statistics 27.0 software were used to perform the statistics of frequency,nature,and flavor attribution,Channel tropism,and efficacy categories of Chinese medicines,association rules,and systematic cluster analysis.Results Fifty-three articles from the literature that met the criteria were included,containing 53 prescriptions,127 Chinese herbal medicines,with a total frequency of 715 times,21 high-frequency Chinese herbal medicines,and most of the high-frequency Chinese herbal medicines with a dosage range of 10 to 30 g.The Chinese medicines with higher frequency of use and dosage were Astragali Radix 30 g,Poria 15 g,Rhei Radix Et Rhizoma 10 g and so on.The medicinal nature were mostly warm,cold,and flat,the flavors were mainly sweet,bitter,and pungent,and the channel tropisms were mostly the liver,spleen,and kidney meridians.The statistics of drug efficacy categories were obtained 16 categories.Association rule analysis yielded 14 sets of core couplet medicines and 13 sets of core dosage pairs.Cluster analysis yielded 10 cluster parties.Conclusion This study reveals to some extent the use of traditional Chinese medicine and its dosage pattern in the treatment of chronic kidney disease(non-dialysis)with spleen and kidney qi deficiency with dampness and stasis,which can provide some reference for the selection of clinical dosage.

关 键 词：慢性肾脏病 脾肾气虚 数据挖掘 中医药 

分 类 号：R256.5[医药卫生—中医内科学]