上呼吸道益生菌Biohalo23用于儿童急性呼吸道感染的安全性及功效  

Safety and Efficacy of Upper Respiratory Tract Probiotic Biohalo23 for Acute Respiratory Tract Infections in Children

作　　者：何明心 刘洋 罗瑞 王强[1,2] HE Ming-xin;LIU Yang;LUO Rui;WANG Qiang(College of Medicine,Wuhan University of Science and Technology,Wuhan 430065,China;Department of Pediatrics,Wuhan Asian General Hospital,Wuhan 430056,China)

机构地区：[1]武汉科技大学医学院,武汉430065 [2]武汉亚心总医院儿科,武汉430056

出　　处：《中国合理用药探索》2024年第8期48-56,共9页Chinese Journal of Rational Drug Use

基　　金：武汉亚心总医院科研创新基金重点项目(2022KYCX1-A04);武汉市武昌医院科研创新基金重点项目(WCYY2022K02)。

摘　　要：目的:评估上呼吸道益生菌Biohalo23用于儿童急性呼吸道感染(ARTI)的安全性及功效。方法:选取2023年6月某院收治的40例ARTI患儿作为研究对象,采用随机数字表法分为对照组和观察组,每组20例。对照组给予常规治疗,观察组在对照组基础上给予Bactoblis致可多活性益生菌复合片(压片糖果)含服,连续干预7天,随访14天。分析两组患儿ARTI病程、用药情况、菌群变化及不良反应发生情况。结果:7天内,观察组患儿退热药使用率低于对照组(P<0.05)。7天内和21天内,观察组患儿ARTI病程、抗菌药物和抗病毒药使用天数短于对照组(P<0.05)。菌群方面,观察组患儿上呼吸道菌群稳定性高于对照组、属水平的菌群丰富度高于对照组;两组患儿菌群组成存在明显差异;在科水平上,观察组患儿乳杆菌科丰度高于对照组;在属水平上,观察组患儿乳杆菌属和魏斯氏菌属丰度高于对照组,而艾肯菌属丰度低于对照组。研究期间,两组患儿未发生不良反应。结论:上呼吸道益生菌Biohalo23有助于调节上呼吸道菌群稳态,减少有害菌定植,可缩短ARTI患儿病程,减少抗菌药物的使用,且具有良好的应用价值。Objective:To evaluate the safety and efficacy of upper respiratory tract probiotic Biohalo23 for acute respiratory tract infection(ARTI)in children.Methods:A total of 40 children with ARTI treated in a hospital in June 2023 were selected and divided into control group and observation group by random number table,with 20 patients in each group.The control group was given conventional treatment,and the observation group was sublingually given Bactoblis®,tablets containing bioactive compounds and probiotic bacteria as tableting candy,in addition to the treatment given in the control group,and intervention was continuously provided for 7 days,with a 14-day follow-up.The duration of ARTI,medication,changes in microbiota and adverse reactions were analyzed in the two groups.Results:Within 7 days,the rate of antipyretic medication in the observation group was lower than that in the control group(P<0.05).Within 7 days and 21 days,the duration of ARTI and the number of days on antimicrobial and antiviral medication in the observation group was shorter than that in the control group(P<0.05).With respect to microbiota,the upper respiratory tract microbiota was more stable and the richness of microbiota at genus level was higher in the observation group as compared with the control group.There were significant differences in the composition of microbiota between the two groups.At the family level,the abundance of Lactobacteriaceae in the observation group was higher than that in the control group;At the genus level,the abundance of Lactobacillus and Weissella was higher,while the abundance of Eikenella was lower in the observation group as compared with the control group.During the study,no adverse reactions occurred in pediatric patients of either group.Conclusion:Upper respiratory tract probiotic Biohalo23 can help regulate the steady state of upper respiratory tract microbiota,reduce the colonization of pernicious bacteria,shorten the duration of ARTI in children and reduce the use of antimicrobial,demonstrating great ap

关 键 词：上呼吸道益生菌 急性呼吸道感染 抗菌药物 上呼吸道菌群稳态 不良反应 

分 类 号：R459.9[医药卫生—治疗学]