Selenium nanoparticles reduce oxidative stress-induced cardiomyocyte apoptosis in ascites syndrome in broiler chickens via the ATF6-DR5 signaling pathway  

作　　者：Xiaoqi Yang Xin Liu Jiaqi Liu Peiling Wu Yang Fu San Loon Kyein Jiabin Zhang Mengdi Zhang Yuxuan Peng Donghai Zhou 

机构地区：[1]College of Veterinary Medicine,Veterinary Clinical Medicine Laboratory,Huazhong Agricultural University,Shizishan Street,Wuhan,CA 430070,China [2]Hainan College of Vocation and Technique,Haikou,China [3]College of Animal Science and Technology,Tarim University,Arar,China

出　　处：《Animal Diseases》2023年第3期153-165,共13页动物疾病（英文）

基　　金：Central Fundamental Research Fund for Universities(No.2662020DKPY013);Thirteenth Five-Year Plan Key R&D Program(No.2016YFD0501208);Innovation and Entrepreneurship Training Program for College Students in Hubei Province(S202110504039).

摘　　要：Broiler ascites syndrome(AS)is one of the main diseases threatening the health of broilers.It is well documented that myocardial hypertrophy and failure is one of the key mechanisms of broiler ascites syndrome.Therefore,prevention of cardiac hypertrophy and failure would be one goal to reduce broiler ascites syndrome incidence.Myocardial hyper-trophy and failure are closely related to endoplasmic reticulum stress(ERS)in cardiac myocytes,and the endoplasmic reticulum stress signaling system(ATF6-DR5)is one of the important pathways of myocardial apoptosis.Excessive hyper-trophy will affect the heart muscle's normal contraction and diastole function,and the heart will turn from compen-sated to decompensate thus causing myocardial injury.Myocardial apoptosis is a core component of the pathological changes of this myocardial injury.Nano-selenium is a kind of red elemental selenium nanoparticle.Due to its excellent physical,chemical and biological properties,it has attracted extensive academic attention in recent years.It has been proven to have excellent antioxidant,antibacterial,antitumor,antihypertrophic,and antiapoptotic abilties.Herein,nano-selenium(1μmol/L)can inhibit hydrogen peroxide(H_(2)O_(2))-induced oxidative stress in broiler primary cardiomyocytes,and at the same time reduce cardiomyocyte apoptosis.In vivo,nano-selenium can reduce broiler myocardial injury-related enzyme indicators(AST,CK and LDH),and alleviate myocardial injury.It can also activate the antioxidant enzyme system(SOD,GSH-Px and CAT)and reduce MDA,and make the recovery ofT-AOC ability in the organization.Meanwhile,nano-selenium can down-regulate the genes and proteins expression of ATF-6,GRP-78,CHOP and caspase 12 in the ERS-related signaling pathway,and inhibit that of downstream-related caspase 3,Bax and caspase 9,and increase that of the downstream anti-apoptotic Bcl-2,thereby maintaining the homeostasis of the endoplasmic reticulum and alleviating cardiomyocyte apoptosis.It can be seen that nano-selenium can protect the damaged myocar

关 键 词：Broiler ascites syndrome Cardiomyocyte apoptosis NANO-SELENIUM ATF6-DR5 signaling pathway 

分 类 号：S856[农业科学—临床兽医学]