基于“伏毒”理论探讨糖尿病肾病的中医药治疗  

Traditional Chinese Medicine Treatment of Diabetic Nephropathy Based on"Latent Toxin"Theory

作　　者：尹希亚 吴进 张忠勇[2] 李华君[2] 王元松[2] YIN Xiya;WU Jin;ZHANG Zhongyong;LI Huajun;WANG Yuansong(Graduate School of Hebei University of Chinese Medicine,Shijiazhuang Hebei China 050000;Department of Endocrinology and Diabetes,Cangzhou Hospital of Integrative Medicine,Cangzhou Hebei China 061000)

机构地区：[1]河北中医药大学研究生学院,河北石家庄050000 [2]河北省沧州中西医结合医院内分泌糖尿病科,河北沧州061000

出　　处：《中医学报》2024年第9期1925-1931,共7页Acta Chinese Medicine

基　　金：全国名老中医专家传承工作室{冀中医药函〔2024〕3号}河北省自然科学基金京津冀基础研究专项项目(H2020110287);河北中医药大学研究生创新能力培养资助项目(XCXZZSS2023019);第七批全国老中医药专家学术经验继承工作项目。

摘　　要：糖尿病肾病(diabetic kidney disease,DKD)的发病在于“伏毒”内蕴,内外之邪裹挟聚而成毒,尤以痰湿、火热、瘀血为甚,外因引动或正虚邪胜致病。中医药治疗DKD以扶正固本、活血化瘀、化痰祛浊、滋阴清热等法选方遣药,疗效确切,可有效延缓病情进展。但目前基于“伏毒”理论探讨DKD的中医药治疗相关研究仍存在一些不足之处,如中药药理作用的研究多局限于某一中药或其单一成分,“伏毒”理论缺少临床试验及科学研究的佐证,今后的研究需进一步挖掘中医理论渊源,探究DKD发病机制,完善其病因病机,为临床研究提供更多的理论依据。The onset of diabetic kidney disease(DKD)lies in the internal stagnation of"latent Toxin",and the internal and external evil factors are engulfed and gathered to form Toxin,especially Phlegm and Dampness,Heat,and blood stasis.External causes disease or the victory of the evil factors in fighting against Zheng Qi causes disease.Traditional Chinese medicine(TCM)in treatment of DKD is based on methods such as strengthening the body′s Zheng Qi,invigorating blood circulation and removing stasis,dissolving Phlegm and Turbidity,nourishing Yin and clearing Heat,etc.,which have definite curative effects and can effectively delay the progression of the disease.However,there are some deficiencies in the current research on the treatment of diabetic nephropathy based on the theory of"latent Toxin",such as the research on the pharmacological effects of TCM is mostly limited to a single TCM or its single component,and there is a lack of clinical observation and scientific research to support the"latent Toxin"theory.Therefore,in future research,there is a need to further explore the theoretical origin of TCM,explore the pathogenesis of DKD,improve its etiology and pathogenesis study,to provide more theoretical basis for clinical research.

关 键 词：“伏毒”理论 糖尿病肾病 扶正固本 活血化瘀 化痰祛浊 滋阴清热 

分 类 号：R256.5[医药卫生—中医内科学]