淋巴/单核细胞比值与老年血液透析患者皮肤瘙痒的相关性分析  

Correlation between lymphocyte/monocyte ratio and skin pruritus in elderly hemodialysis patients

作　　者：覃新芳[1] 邹迪莎 李康慧[1] 王颖 李召荣 QIN Xinfang;ZOU Disha;LI Kanghui;WANG Ying;LI Zhaorong(Department of Neonatology,Affiliated Hospital of Guilin Medical University,Guilin 541001,China)

机构地区：[1]桂林医学院附属医院肾内科,桂林541001

出　　处：《华夏医学》2024年第3期69-74,共6页Acta Medicinae Sinica

基　　金：广西高校中青年教师科研基础能力提升项目(2020KY12022);广西中医药局自筹项目(GZZC2019141);桂林医学院中青年教职工科研能力提升项目(2018glmcy056)。

摘　　要：目的探讨淋巴/单核细胞比值(LMR)与老年维持性血液透析(MHD)患者皮肤瘙痒的相关性。方法收集74例老年MHD患者的临床资料,并计算LMR,根据中文版14-Item UP-Dial Scale量表问卷分无、轻度、中度、重度瘙痒,比较不同瘙痒组的临床资料,使用Logistic回归模型分析皮肤瘙痒患者的影响因素。结果糖尿病肾病老年患者的瘙痒评分高于其他原发病组,LMR水平在各组原发病的老年患者中差异无统计学意义(P>0.05)。无瘙痒组与瘙痒各组的老年患者的空腹血糖、糖化血红蛋白、URR、直接胆红素、LMR比较,差异具有统计学意义(P<0.05)。多因素Logistic回归分析显示,LMR为瘙痒的独立保护因素(P<0.05)。结论LMR与老年MHD患者的皮肤瘙痒有相关性。Objective To explore the correlation between lymphocyte/monocyte ratio(LMR)and pruritus in elderly patients with maintenance hemodialysis(MHD).Methods The clinical data of 74 elderly patients with MHD were collected,and LMR was calculated.According to the Chinese 14-Item UP-Dial Scale questionnaire,the patients were divided into no,mild,moderate and severe pruritus groups.The clinical data of different pruritus groups were compared,and the influencing factors of pruritus patients were analyzed by Logistic regression model.Results The itch score of elderly patients with diabetic nephropathy was significantly higher than that in other primary disease group.There was no statistical difference in the level of LMR among all groups with primary disease(P>0.05).The fasting blood glucose,glycated hemoglobin,urea reduction rate(URR),direct bilirubin and LMR of elderly patients between the no-itch group and each itch groups were compared.The differences were statistically significant(P<0.05),and multiple Logistic regression analysis showed that LMR was an independent protective factor for pruritus(P<0.05).Conclusion LMR is associated with pruritus in elderly with patients.

关 键 词：淋巴/单核细胞 维持性血液透析 皮肤瘙痒 

分 类 号：R692.5[医药卫生—泌尿科学]