生物模拟纳米药物在类风湿关节炎治疗中的研究进展  

Research progress of biomimetic nanomedicine in the treatment of rheumatoid arthritis

作　　者：赵红鱼 董秋梅 敖丽梅 ZHAO Hongyu;DONG Qiumei;AO Limei(College of Traditional Chinese Medicine,Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Hohhot010000,China)

机构地区：[1]内蒙古医科大学中医学院,内蒙古呼和浩特010000

出　　处：《中国医药导报》2024年第22期46-50,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(82360887);内蒙古自治区自然科学基金项目(2022QN08007);内蒙古自治区教育厅高等学校科学技术研究项目(NJZZ22672);内蒙古医科大学面上项目(YKD2022MS080);内蒙古医科大学生科技创新“英才培育”项目(YCPY2023003)。

摘　　要：类风湿关节炎(RA)是一种严重影响患者生活质量的全身性自身免疫性疾病。非甾体抗炎药和改善病情抗风湿药虽能缓解RA症状,但伴随显著副作用且疗效有限。生物模拟纳米药物通过模仿体内天然结构和功能,提升药物生物相容性和靶向性,减少免疫原性和副作用,展现巨大的治疗潜力。这些纳米药物可调节免疫细胞功能、控制炎症介质释放并靶向递送抗炎因子,有效减轻RA症状并防止关节损伤。尽管面临长期安全性、生产复杂性及个体差异等挑战,但生物模拟纳米药物在RA治疗中仍具有广阔前景。优化设计和制造工艺,研究代谢行为和长期安全性,发展个体化治疗策略,将进一步推动其临床应用,为患者提供更安全有效的治疗方案。Rheumatoid arthritis(RA)is a systemic autoimmune disease that severely impacts patients’quality of life.Although nonsteroidal anti-inflammatory drugs and disease modifying anti-rheumatic drugs can alleviate RA symptoms,they are accompanied by significant side effects and have limited efficacy.Biomimetic nanomedicine enhances drug biocompatibility and targeting by mimicking natural structures and functions in the body,reducing immunogenicity and side effects,and demonstrating enormous therapeutic potential.These nanomedicines can regulate immune cell function,control the release of inflammatory mediators,and target the delivery of anti-inflammatory factors,effectively reducing RA symptoms and preventing joint damage.Despite facing challenges such as long-term safety,production complexity and individual differences,biomimetic nanomedicine still has broad prospects in RA treatment.Optimizing design and manufacturing processes,studying metabolic behavior,and long-term safety,and developing personalized treatment strategies will further promote their clinical application and provide patients with safer and more effective treatment plans.

关 键 词：类风湿关节炎 生物模拟纳米药物 炎症调节 靶向治疗 免疫调控 

分 类 号：R593.22[医药卫生—内科学]