医用缝合线的成型加工制备及功能化研究进展  

Progress in the preparation and functionalisation of medical sutures by molding and processing

作　　者：张琪禄 王黎明[1] 徐丽慧[1] 姚程健 ZHANG Qilu;WANG Liming;XU Lihui;YAO Chengjian(Shanghai University of Engineering Science,School of Textiles and Fashion,Shanghai 201600,China)

机构地区：[1]上海工程技术大学纺织服装学院,上海201600

出　　处：《上海纺织科技》2024年第8期18-23,37,共7页Shanghai Textile Science & Technology

基　　金：国家自然科学基金项目(51703123);上海市自然科学基金项目面上项目(21ZR1426200)。

摘　　要：外科手术缝合线在临床上是重要的伤口缝合医疗器械。临床使用的功能型外科缝线能够对伤口进行牵引闭合,最大限度地促进伤口愈合、缓解炎症。缝合线分为可吸收和不可吸收两种,因材料和结构的差异,它们具有不同的力学和降解周期。近年来,功能性纤维材料的研究提高了缝线的临床使用效果。然而,缝线的临床使用仍面临一些问题。优化缝线表面摩擦力、打结强度,对缝线进行抗菌、抗炎等功能化,都是促使缝线使用后对组织再生、闭合起到美容、抑制疤痕效果的良好改性方法。综述了用于缝合线的原材料,包括可吸收和不可吸收缝合线;缝合线的加工方式,包括编织、静电纺丝、熔融挤出;缝合线不同功能修饰的研究进展,包括抗菌、抗炎及缓释功能化。Surgical sutures are important medical devices for wound closure in clinical practice.Functional surgical sutures utilized in clinical settings effectively appose wound edges,optimize wound healing,and mitigate inflammation.These sutures fall into two categories:absorbable and non-absorbable,each exhibiting distinct mechanical properties and degradation timelines attributable to variances in materials and structures.Recent research in functional fiber materials has bolstered the clinical efficacy of sutures.Nonetheless,challenges persist in their clinical application.Refining suture surface friction,bolstering knot strength,and incorporating features such as antimicrobial and anti-inflammatory properties represent efficacious modification strategies that facilitate tissue regeneration,closure,aesthetic outcomes,and scar mitigation subsequent to suture deployment.A comprehensive overview encompassing the following dimensions is made:The raw materials employed in sutures,encompassing both absorbable and non-absorbable variants;Techniques employed in suture fabrication,encompassing weaving,electrospinning,and melt extrusion;Strides made in functionally enhancing sutures,encompassing advancements in antimicrobial,anti-inflammatory,and controlled-release functionalities.

关 键 词：医用纺织品 医用缝合线 编织 涂层 水凝胶 

分 类 号：TS101.4[轻工技术与工程—纺织工程] R608[轻工技术与工程—纺织科学与工程]