酪酸梭菌辅助治疗对癫痫患者肠道菌群分布及肠道黏膜通透性的影响  

The effect of adjuvant therapy with Clostridium butyricum on the distribution of intestinal microbiota and intestinal mucosal permeability in epilepsy patients

作　　者：吴岳彪 蔡露良 林鲁飞 WU Yuebiao;CAI Luliang;LIN Lufei(Department of Pediatrics,Haikou Fourth People's Hospital,Haikou,Hainan 571100,China)

机构地区：[1]海口市第四人民医院儿科,海南571100

出　　处：《中国微生态学杂志》2024年第7期817-820,827,共5页Chinese Journal of Microecology

摘　　要：目的研究酪酸梭菌辅助治疗对癫痫的治疗作用,分析其对患者肠道菌群分布及肠黏膜通透性的影响。方法将2019年6月至2021年6月于我院就诊的110例癫痫患者纳为研究对象,按随机数表法分为对照组和研究组,各55例。对照组患者采取常规抗癫痫治疗,研究组在对照组基础上予以酪酸梭菌治疗,均持续治疗6个月。评估两组患者癫痫治疗效果,并比较其治疗前后的肠道菌群和肠黏膜通透性变化,同时观察用药安全性。结果研究组患者癫痫发作情况和脑电图颠痫样放电治疗效果均优于对照组(均P<0.05)。治疗后,研究组患者肠道大肠埃希菌数量减少,肠球菌、双歧杆菌及乳杆菌数量增加(均P<0.05);同时L/M值、D-乳酸及内毒素水平降低(均P<0.05)。对照组患者治疗前后上述指标水平无显著变化(均P>0.05)。两组患者均无严重不良反应(P>0.05)。结论酪酸梭菌辅助治疗癫痫的效果显著,能改善患者肠道菌群分布,降低肠道黏膜通透性,安全性高。Objective To observe the effect of adjuvant therapy with Clostridium butyricum on the distribution of intestinal microbiota and intestinal mucosal permeability in epilepsy patients,providing a reference for the treatment.Methods A total of 110 epilepsy patients who admitted to our hospital from June 2019 to June 2021 were enrolled and randomly divided into a control group and an observation group with 55 cases each.Both groups received conventional antiepileptic treatment,while the observation group received additional Clostridium butyricum treatment for 6 months.The effectiveness of epilepsy treatment in the two groups were evaluated.The changes in intestinal microbiota and mucosal permeability before and after treatment were compared,and the safety of medication was observed.Results The curative effects of epilepsy and epileptiform discharge of EEG in the observation group were better than those in the control group(all P<0.05).After treatment,the intestinal E.coli decreased while Enterococcus,Bifidobacterium and Lactobacillus increased in the observation group(all P<0.05);LM,D-lactic acid and endotoxin decreased in the observation group(P<0.05).There were no significant changes in these indicator levels in the control group after treatment(all P>0.05).There were no serious adverse reactions in either group(P<0.05).Conclusion Clostridium butyricum is effective as an adjuvant treatment of epilepsy,which can improve the distribution of intestinal microbiota,reduce intestinal mucosal permeability,and has high safety.

关 键 词：酪酸梭菌 癫痫 肠道菌群 肠黏膜通透性 安全性 

分 类 号：R452[医药卫生—治疗学]