一种免洗速干手消毒剂消毒性能的相关研究  

Disinfection performance of a free hand-quick-drying hand sanitizer

作　　者：周于 张天宝[2] 苏贵斌 周剑 晏强 姜朴[1] 唐非[1] ZHOU Yu;ZHANG Tian-bao;SU Gui-bin;ZHOU Jian;YAN Qiang;JIANG Pu;TANG Fei(Institute of Environmental Medicine,MOE Key Laboratory of Environment and Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Hubei Provincial Center for Disease Control and Prevention;Wuhan Tongji Medison Technology Co.)

机构地区：[1]华中科技大学同济医学院公共卫生学院环境医学研究所,环境与健康教育部重点实验室,湖北武汉430030 [2]湖北省疾病预防控制中心 [3]武汉同济美迪生科技有限公司

出　　处：《中国消毒学杂志》2024年第8期569-572,共4页Chinese Journal of Disinfection

摘　　要：目的检测一种免洗速干过氧化氢-乙醇手消毒剂的消毒相关性能及毒性。方法采用悬液定量杀灭试验、理化试验和动物毒性试验方法,检测该消毒剂对细菌、真菌及病毒的杀灭性能及其安全性。结果该手消毒剂以过氧化氢和乙醇为主要复合杀菌组分,过氧化氢含量为1470 mg/L,乙醇含量为体积分数80.1%。用该手消毒剂原液作用0.5、1.0、1.5 min,对金黄色葡萄球菌、大肠埃希菌和铜绿假单胞菌的杀灭对数值均>6.00,对白念珠菌平均杀灭对数值>5.00;对脊髓灰质炎病毒Ⅰ型疫苗株的平均灭活对数值>4.00;用该手消毒剂原液作手擦拭消毒,作用1 min对手上自然菌的杀灭对数值>1.00。该手消毒剂密封包装经37℃储存3个月,其有效成分含量下降率均<10%;该手消毒剂的皮肤刺激试验结果表明属无刺激性;急性经口毒性试验结果表明,对小鼠的毒性属实际无毒;小鼠骨髓嗜多染红细胞微核试验呈阴性。结论该过氧化氢-乙醇手消毒剂对细菌繁殖体、真菌和病毒均具有快速杀灭效果,属实际无毒级物质,其储存性能稳定。Objective To test the disinfection-related performance and toxicity of hydrogen peroxide-ethanol free hand-drying hand sanitizer.Methods Quantitative suspension killing test,physical and chemical test,animal toxicity test methods were used to test the killing performance and safety of the disinfectant.Results The hand sanitizer has hydrogen peroxide and ethanol as the main composite germicidal components,with hydrogen peroxide content of 1470 mg/L and ethanol content of 80.1%by volume.After 0.5,1.0 and 1.5 min of the hydrogen peroxide-ethanol hand sanitizer,the killing log value of Staphylococcus aureus,Escherichia coli and Pseudomonas aeruginosa were all>6.00,and the average killing log value of Candida albicans was>5.00,and the average killing log value of the poliovirus-Ⅰvaccine strain was>4.00.The hand disinfectant liquid was used for hand wipe disinfection,and the killing log value of natural bacteria on the hand after 1 min was>1.00.The disinfectant sealed package was stored at 37℃for 3 months,and the reduction rates of its effective ingredient content were all less than 10%.The skin irritation test results of this hand sanitizer showed that it was non-irritating.The results of the acute oral toxicity test showed that the hand sanitizer was practically non-toxic to mice.The result of micronucleus test for mouse bone marrow polychromatic redblood cells was negative.Conclusion This hydrogen peroxideethanol hand sanitizer has a rapid killing effect on bacterial propagules,fungi and viruses.It is practically non-toxic and has stable storage properties.

关 键 词：手消毒剂 细菌 真菌 病毒 消毒效果 

分 类 号：R187[医药卫生—流行病学]