某复配型季铵盐消毒剂低温下的消毒效果及相关性能研究  

Disinfection effect and related performance of a compound quaternary ammonium salt disinfectant at low temperature

作　　者：张福娥[1] 乔映宇 任宇灵 李淑琴[1] 王静[1] ZHANG Fu-e;QIAO Ying-yu;REN Yu-ling;LI Shu-qin;WANG Jing(Shanxi Provincial Center for Disease Control and Prevention,Taiyuan 030012,China;Shanxi Medical University)

机构地区：[1]山西省疾病预防控制中心,山西太原030012 [2]山西医科大学

出　　处：《中国消毒学杂志》2024年第8期576-578,共3页Chinese Journal of Disinfection

摘　　要：目的研究以乙二醇为防冻剂的某种复配型季铵盐消毒剂在低温下的消毒效果及其金属腐蚀性和毒性。方法-18℃条件下,500 mg/L复配型季铵盐消毒剂分别对试验菌作用3、6和9 min,评价其消毒效果;通过对不锈钢、碳钢、铜、铝的腐蚀速率评价其金属腐蚀性,通过急性经口毒性试验、皮肤刺激试验和急性眼刺激试验进行消毒剂安全性毒理学评价。结果-18℃条件下,500 mg/L消毒剂作用9 min,对载体上的大肠埃希菌和金黄色葡萄球菌杀灭对数值分别为3.46和>6.04;对不锈钢、碳钢、铜、铝的腐蚀速率分别为0.0035、0.0138、0.0152和0.0075 mm/a;5倍浓度低温应用液对雌雄小鼠急性经口LD50均>5000 mg/(kg·bw),对家兔一次完整皮肤刺激试验和急性眼刺激试验均属无刺激性。结论该复配型季铵盐消毒剂在低温下有较强的杀菌效果,且对金黄色葡萄球菌的杀灭效果优于大肠埃希菌;对不锈钢和铝基本无腐蚀,安全性好。Objective To study the disinfection effect,corrosive effect on metals and toxicity to experimental animals of a certain compound quaternary ammonium disinfectant with ethylene glycol as antifreeze at low temperature.Methods Under the condition of-18°C,the disinfection effect of 500 mg/L compound quaternary ammonium salt disinfectant was evaluated with incubating the test bacteria for 3,6 and 9 min,respectively.The corrosion rates of stainless steel,carbon steel,copper and aluminum were evaluated,and the safety toxicology of disinfectants was evaluated by acute oral toxicity test,skin irritation test and acute eye irritation test.Results At-18°C,the killing log values of 500 mg/L disinfectant against Escherichia coli and Staphylococcus aureus on the carrier were 3.46 and>6.04,respectively.Corrosion rates(mm/a)of stainless steel,carbon steel,copper and aluminum by 500 mg/L disinfectant were 0.0035,0.0138,0.0152 and 0.0075 mm/a,respectively.The acute oral LD50 of 5 times concentration of the disinfectant was>5000 mg/(kg·bw)in both male and female mice.It was nonirritating in a complete skin irritation test and acute eye irritation test in rabbits.Conclusion The compound quaternary ammonium salt disinfectant has a strong bactericidal effect at low temperature.It is basically non-corrosive to stainless steel and aluminum,and has good safety.

关 键 词：季铵盐消毒剂 细菌繁殖体 杀菌效果 毒性 

分 类 号：R187[医药卫生—流行病学]