寻常型银屑病患者马拉色菌感染的临床特征及NLRP3炎症小体、IL-10、IFN-γ、SP表达意义  

Clinical features and the expression significance of NLRP3 inflammatome,IL-10,IFN-γ and SP of Malassezia infection in patients with psoriasis vulgaris

作　　者：邹建飞 亓秀丽 徐玉玲 袁飞飞 尚念秀 ZOU Jian-fei;QI Xiu-li;XU Yu-ling;YUAN Fei-fei;SHANG Nian-xiu(Shandong First Medical University Affiliated People's Hospital,Jinan,Shandong 271199,China)

机构地区：[1]山东第一医科大学附属人民医院皮肤科,山东济南271199

出　　处：《中华医院感染学杂志》2024年第15期2357-2361,共5页Chinese Journal of Nosocomiology

基　　金：山东省医药卫生科技发展计划项目(2018WS0535)。

摘　　要：目的探究寻常型银屑病(PSO)患者马拉色菌感染的临床特征及血清核苷酸结合寡聚结构域样受体蛋白3(NLRP3)炎症小体、白细胞介素(IL)-10、干扰素-γ(IFN-γ)、P物质(SP)表达意义.方法选取山东第一医科大学附属人民医院2019年9月—2023年9月收治的PSO患者发生马拉色菌感染101例作为研究组,根据研究组的感染严重程度分为轻度组(25例)、中度组(35例)、重度组(41例),另选103例PSO患者未发生马拉色菌感染作为对照组;比较研究组、对照组之间,轻度组、中度组、重度组之间NLRP3炎症小体、IL-10、IFN-γ、SP表达情况;采用Spearman分析NLRP3炎症小体、IL-10、IFN-γ、SP水平与PSO患者马拉色菌感染及感染严重程度的相关性.结果研究组NLRP3炎症小体、IFN-γ、SP水平高于对照组,IL-10水平低于对照组(P<0.05);重度组NLRP3炎症小体、IFN-γ、SP水平高于中度组和轻度组,且中度组高于轻度组(P<0.05);重度组IL-10水平低于中度组和轻度组,且中度组低于轻度组(P<0.05);NLRP3炎症小体、IFN-γ、SP水平与PSO患者马拉色菌感染均呈正相关(r=0.612、0.625、0.683,P<0.05),IL-10则呈负相关(r=-0.597,P<0.05),NLRP3炎症小体、IFN-γ、SP水平与PSO患者感染严重程度均呈正相关(r=0.572、0.679、0.537,P<0.05),IL-10则呈负相关(r=-0.603,P<0.05).结论PSO马拉色菌感染患者的NLRP3炎症小体、IFN-γ、SP水平高表达,IL-10水平低表达,且这些因子与PSO患者马拉色菌感染及感染严重程度均有相关性.OBJECTIVE To investigate the clinical features and the expression significance of serum nucleotide-bind-ing oligomeric domain-like receptor protein 3(NLRP3)inflammatome,interleukin(IL)-10,interferon-γ(IFN-γ)and Substance P(SP)of Malazzia infection in patients with psoriasis vulgaris(PSO).METHODS A total of 101 cases of Malassezia infection in PSO patients admitted to People's Hospital of Shandong Affiliated to First Medical University from Sep 2019 to Sep 2023 were selected as the study group.According to the severity of infection,the study group was divided into the mild group(25 cases),the moderate group(35 cases)and the severe group(41 cases).Another 103 patients with PSO without Malassezia infection were included in the control group.The ex-pression levels of NLRP3 inflammasome,IL-10,IFN-γand SP between the study group and control group,a-mong the mild group,the moderate group and the severe group were compared.Spearman was used to analyze the correlation of NLRP3 inflammatome,IL-10,IFN-γ,SP levels with Malaxia infection and severity of infection.RESULTS The levels of NLRP3 inflammasome,IFN-γand SP in the study group were higher than those in the control group,while the levels of IL-10 were lower than that in the control group(P<0.05).The levels of NL-RP3 inflammasome,IFN-γand SP in the severe group were higher than those in the moderate group and the mild group,and the moderate group was higher than the mild group(P<0.05).The level of IL-10 in the severe group was lower than that in the moderate group and the mild group,and the moderate group was lower than that in the mild group(P<0.05).The levels of NLRP3 inflammasome,IFN-γand SP were positively correlated with Malas-zia infection in PSO patients(r=0.612,0.625,0.683,P<0.05),while IL-10 was negatively correlated with Malaszia infection(r=-0.597,P<0.05).NLRP3 inflammatome,IFN-γand SP levels were positively correla-ted with the severity of infection in PSO patients(r=0.572,0.679,0.537,P<0.05),while IL-10 was nega-tively correlated with the severity of

关 键 词：寻常型银屑病 马拉色菌 核苷酸结合寡聚结构域样受体蛋白3 白细胞介素-10 干扰素-Γ P物质 感染严重程度 相关性 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]