滋水清肝饮加味方治疗肝郁肾虚型抑郁症的临床研究  

Clinical Study on Modified Zishui Qinggan Decoction(滋水清肝饮加味方)in the Treatment of Depression of Liver Depression and Kidney Deficiency Type

作　　者：胡域锋 王革生[2] 裴清华 郑粲 HU Yufeng;WANG Gesheng;PEI Qinghua;ZHENG Can(The Third Clinical School of Beijing University of Chinese Medicine,Beijing 100029,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学第三临床医学院,北京100029 [2]北京中医药大学东方医院,北京100078

出　　处：《中医药导报》2024年第8期87-91,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015043)。

摘　　要：目的:评价滋水清肝饮加味方治疗肝郁肾虚型抑郁症的临床疗效。方法:将72例肝郁肾虚型轻中度抑郁症患者随机分为试验组与对照组,每组36例。试验组患者口服滋水清肝饮加味方联合氟西汀,对照组患者单独口服氟西汀。疗程6周。采用汉密尔顿抑郁量表评分和中医证候评分对患者表现评价。结果:试验组抗抑郁效果优于对照组(P<0.05)。HAMD总分与中医证候总分在时间点比较及交互作用均有明显差异(P<0.05)。两组患者在治疗2、4、6周时HAMD总分和中医症状评分均低于治疗前(P<0.05)。HAMD评分结果显示,与对照组相比,试验组抑郁情绪、入睡困难、躯体性焦虑、强迫症状等改善明显,而工作和兴趣、能力减退、绝望感则无明显改善。结论:滋水清肝饮加味方加氟西汀治疗肝郁肾虚型轻中度抑郁症优于氟西汀单药治疗。该治疗方法在减轻焦虑和抑郁症状、躯体化不适和改善睡眠质量等方面疗效优异。Objective:To evaluate the clinical efficacy of Modified Zishui Qinggan Decoction in the treatment of depression with liver depression and kidney deficiency.Methods:A total of 72 patients with mild to moderate depression of liver depression and kidney deficiency were randomly divided into experimental group and control group,36 cases in each group.Patients in the experimental group were treated with Modified Zishui Qinggan Decoction combined with fluoxetine,while patients in the control group were treated with fluoxetine alone.The course of treatment was 6 weeks.The Hamilton Depression Scale score and TCM syndrome score were used to evaluate the patient's performance.Results:The antidepressant effect of the experimental group was better than that of the control group(P<0.05).There were significant differences between the total score of HAMD and the total score of TCM syndromes at the time point and the interaction(P<0.05).The HAMD total score and TCM symptom score of the two groups at 2,4 and 6 weeks of treatment were lower than those before treatment(P<0.05).The results of HAMD score showed that compared with the control group,the depression,difficulty falling asleep,somatic anxiety and obsessive-compulsive symptoms of the experimental group were significantly improved,while the work and interest,ability loss and despair were not significantly improved.Conclusion:Modified Zishui Qinggan Decoction combined with fluoxetine is superior to fluoxetine monotherapy in the treatment of mild to moderate depression with liver depression and kidney deficiency.This treatment has excellent efficacy in reducing anxiety and depression symptoms, somatic discomfort and improving sleep quality.

关 键 词：抑郁症 肝郁肾虚 滋水清肝饮加味方 氟西汀 

分 类 号：R277.7[医药卫生—中医学]