新型冠状病毒感染急性咳嗽患者的中医证素分布特点研究  

Study on the Distribution Characteristics of Tranditional Chinese Medicine Syndrome Elements in Patients with Acute Cough Infected by Novel Coronavirus

作　　者：樊佳慧 唐雪春[1] 吴友强 李柏辰 FAN Jiahui;TANG Xuechun;WU Youqiang;LI Bochen(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《中医药导报》2024年第8期137-143,共7页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨新型冠状病毒感染急性咳嗽患者的中医证素分布特点。方法:采用临床流行病学研究方法,选取2022年12月至2023年12月于北京中医药大学东直门医院门诊诊断为新型冠状病毒感染急性咳嗽的患者,采用证素辨证方法研究其病位、病性证素,并进行关联分析及聚类分析。结果:共收集有效病例130例,共归纳出病位证素9个,病位证素按出现频率依次为肺、表、肝、肾、脾、心神、半表半里、胃、筋骨,其中肺出现频率为100%,提示本病核心病位为肺,其次为表。病性证素16个,按出现频率依次为痰、阴虚、气虚、热、外风、阳虚、湿、寒、血虚、气滞、饮、阳亢、不固、燥、毒、血热,其中痰、阴虚、气虚为主要病性证素。关联分析后得到支持度和置信度最高的组合是肺-表,其次为肺-痰、肺-阴虚。聚类分析后可得到4个聚类组:气滞、肝、外风、寒;湿、热、阴虚;阳虚、气虚、血虚;表、肺、痰。结论:新型冠状病毒感染急性咳嗽的主要病位为肺、表;主要病性为痰、阴虚。痰是新型冠状病毒感染急性咳嗽最主要的病理因素,病机尤以虚(气阴两虚)与痰(痰浊阻络)最为关键,多易由实转虚,虚实夹杂,治疗应虚与痰同治,同时需及时补益肺气、肺阴。Objective:To explore the distribution characteristics of tranditional Chinese medicine syndrome elements in acute cough caused by novel coronavirus infection.Methods:The clinical epidemiological research method was used to select the patients diagnosed as acute cough infected by novel coronavirus in the outpatient department of Dongzhimen Hospital of Beijing University of Chinese Medicine from November 2022 to November 2023,and the syndrome element differentiation method was used to study the disease location and disease syndrome elements,and the correlation analysis and cluster analysis were carried out.Result:A total of 130 effective cases were collected in this study,and a total of 9 elements of disease location were summarized.According to the frequency of disease location,they were lung,surface,liver,kidney,spleen,heart and mind,half surface and half interior,stomach,and bones.The frequency of lung occurrence was 100%,indicating that the core disease location of this disease is lung,followed by surface.There are 16 pathological syndrome elements,which are phlegm,Yin deficiency,Qi deficiency,heat,external wind,Yang deficiency,dampness,cold,blood deficiency,Qi stagnation,Yin,Yang hyperactivity,non consolidation,dryness,toxin,and blood heat according to their frequency of occurrence.Among them,phlegm,Yin deficiency,and Qi deficiency are the main pathological syndrome elements.After correlation analysis,the combination with the highest support and confidence was found to be lung-surface,followed by lung-phlegm and lung-Yin deficiency.After clustering analysis,4 clustering groups can be obtained:Qi stagnation,liver,external wind,and cold.Dampness,heat,and Yin deficiency.Yang deficiency,Qi deficiency,and blood deficiency.Surface,lungs,phlegm.Conclusion:The main location of acute cough caused by novel coronavirus infection is lung surface.The main pathologica features are phlegm and Yin deficiency. Phlegm is the most important pathological factor of acute cough caused by novel coronavirus infection, and the pathoge

关 键 词：新型冠状病毒感染 急性咳嗽 中医 证素 聚类分析 关联分析 

分 类 号：R256.11[医药卫生—中医内科学]