不同透皮吸收促进剂及组合对烟酰胺凝胶体外透皮吸收的影响  

Effect of different transdermal absorption promoters and combinations on the absorption effect of nicotinamide gal

作　　者：林静 苏振宏 宋强 张正悬 童和林[3] 黄敏[4] 黄志 袁璐 LIN Jing;SU Zhen-hong;SONG Qiang;ZHANG Zhen-xuan;TONG He-lin;HUANG Min;HUANG Zhi;YUAN Lu(School of Medicine,Hubei Polytechnic University,Huangshi Hubei 435003,China;Huangshi Center For Food and Drug Control,Huangshi Hubei 435000,China;Huangshi Central Hospital,Huangshi Hubei 435000,China;Renmin Hospital of Wuhan University,Wuhan 430060,China;Zhejiang Chinese Medical University-Chinese Herbal Pieces Co.,Ltd.Hangzhou 311401,China;Hubei Meierli Biotechnology Co.,Ld,Huangshi 435000,China)

机构地区：[1]湖北理工学院医学院,湖北黄石435003 [2]黄石市食品药品检验检测中心,湖北黄石435000 [3]黄石市中心医院,湖北黄石435000 [4]武汉大学人民医院,湖北武汉430060 [5]浙江中医药大学中药饮片有限公司,浙江杭州311403 [6]湖北美尔丽生物科技有限公司,湖北黄石435000

出　　处：《时珍国医国药》2024年第7期1636-1639,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(22207033);湖北省自然科学基金(2022CFB970)。

摘　　要：目的研究不同透皮吸收促进剂及组合对烟酰胺凝胶体外透皮吸收效果的影响。方法采用Franz扩散池法,以小鼠腹部皮肤作为透皮屏障,用紫外-可见分光光度法测定接收液中烟酰胺的浓度,计算烟酰胺12h的累计渗透量(Q),考察不同的透皮吸收促进剂月桂氮?酮、卡必醇、二甲基亚砜、桉叶油、丁香油及它们组合使用的促渗透效果。结果每种含透皮吸收促进剂的烟酰胺凝胶的Q最高的分别是1%月桂氮卓酮(493.23±32.74)μg·cm^(-2)、1%卡必醇(607.14±37.79)μg·cm^(-2)、2%二甲基亚砜(657.6±39.37)μg·cm^(-2)、1%桉叶油(684.26±30.86)μg·cm^(-2)、1%丁香油(714.83±42.92)μg·cm^(-2),1%桉叶油+1%丁香油(689.38±34.45)μg·cm^(-2)。结论不论单一透皮吸收促进剂,还是透皮吸收促进剂组合均能促进烟酰胺的透皮渗透(P<0.05),其中1%丁香油对促进烟酰胺凝胶中烟酰胺的体外透皮吸收作用最佳。Objective To study the effect of different transdermal absorption promoters and combinations on the transdermal absorption effect of nicotinamide gal.Methods Franz diffusion cell was used for in vitro osmotic experiment.The abdominal skin of mice was used as the test skin.The concentration of nicotinamide in the receiving solution was determined by UV spectrophotometry,and the cumulative release amount of nicotinamide(Q)was calculated.Research the effect of laurocapram,diethylene glycol monoethyl ether,DMSO,eucalyptus oil,clove volatile oil and combined transdermal absorption promoters..Results Q of nicotinamide gel with the best Single transdermal absorptions were 1%Laurocapram(493.23±32.74)μg·cm^(-2),1%Diethylene glycol monoethyl ether(607.14±37.79)μg·cm^(-2),2% DMSO(657.6±39.37)μg·cm^(-2),1% eucalyptus oil(684.26±30.86)μg·cm^(-2),1% clove volatile oil(714.83±42.92)μg·cm^(-2),1% eucalyptus oil+1% clove volatile oil(689.38±34.45)μg·cm^(-2).Conclusion Single and combined both have the effect of transdermal absorption,among all transdermal absorption promoters 1% clove volatile oil has the best effect.

关 键 词：烟酰胺凝胶 透皮吸收促进剂 透皮吸收 紫外-可见分光光度法 

分 类 号：R94[医药卫生—药剂学]