三妙解毒液溻渍治疗湿热壅盛型糖尿病足溃疡的临床疗效观察  

Clinical Observation on Treatment of Diabetic Foot Ulcer with excessive Damp-heat by Sanmiao Jiedu Liquid Fomentation

作　　者：张筱茜 王雁南[2] 范琦琛 王艮一 李涵泊 ZHANG Xiao-qian;WANG Yan-nan;FAN Qi-chen;WANG Gen-yi;LI Han-bo(Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan Shandong,250014,China;Jinan Hospital of Traditional Chinese Medicine,Jinan Shandong,250000,China;Zhangdian District Hospital of Traditional Chinese Medicine,Zibo Shandong,255022,China;Shandong University of Traditional Chinese Medicine,Jinan Shandong,250014,China)

机构地区：[1]上海中医药大学,上海201203 [2]山东中医药大学附属医院,山东济南250014 [3]济南市中医医院,山东济南250000 [4]张店区中医院,山东淄博255022 [5]山东中医药大学,山东济南250014

出　　处：《时珍国医国药》2024年第7期1652-1655,共4页Lishizhen Medicine and Materia Medica Research

基　　金：山东省中医药科技发展计划项目(2019-0202);齐鲁医派中医学术流派传承项目[鲁卫函[2022]93号];全国名老中医药专家传承工作室建设项目[国中医药人教函[2022]75号]。

摘　　要：目的观察三妙解毒液溻渍治疗湿热壅盛型糖尿病足溃疡的临床疗效。方法选取符合标准的湿热壅盛型糖尿病足溃疡患者,随机分为观察组和对照组。两组均给予常规基础治疗,在此基础上观察组予以三妙解毒液局部溻渍,对照组予以康复新液局部溻渍,共治疗14天。收集两组患者的一般资料(性别、年龄、溃疡病程);观察并对比两组患者治疗前后的创面面积、中医证候评分和血清TNF-α、IL-6水平;评价两组患者的疗效及安全性指标。结果(1)观察组患者治疗后的总有效率优于对照组(P<0.05)。(2)观察组患者治疗后的创面面积较治疗前缩小(P<0.05),且优于对照组(P<0.05)。(3)两组患者治疗后的中医证候评分较治疗前均降低(P<0.05),且观察组优于对照组(P<0.05);两组患者治疗后的各项症状评分较治疗前均降低(P<0.05),其中观察组的创面脓液色泽评分、创面肉芽色泽评分与创面肉芽颗粒评分均优于对照组(P<0.05)。(4)两组患者治疗后的血清TNF-α、IL-6水平较治疗前均降低(P<0.05),且观察组优于对照组(P<0.05)。两组患者在治疗过程中均未出现不良事件。结论三妙解毒液溻渍治疗可改善湿热壅盛型糖尿病足溃疡患者肢体局部症状,促进创面愈合,并降低血清TNF-α、IL-6水平。Objective To observe the clinical efficacy of Sanmiao Jiedu Liquid fomentation in treating diabetic foot ulcer with excessive damp-heat.Methods Diabetic foot ulcer patients with excessive damp-heat were selected and randomly divided into observation group and control group.Both groups were given conventional basic treatment.On this basis,the observation group was treated with Sanmiao Jiedu Liquid and the control group was treated with Kangfuxin Liquid for 14 days.The general data(gender,age,course of ulcer)of the two groups were collected.Wound area,traditional Chinese medicine(TCM)syndrome score and serum TNF-αand IL-6 levels of the two groups before and after treatment were observed and compared.The efficacy and safety indexes of the two groups were evaluated.Results(1)The total effective rate of patients in the observation group after treatment was superior to that in the control group(P<0.05).(2)The wound area of patients in the observation group after treatment was smaller than that before treatment(P<0.05),and it was better than that in the control group(P<0.05).(3)TCM syndrome scores of patients in the two groups after treatment were lower than those before treatment(P<0.05),and the observation group was superior to the control group(P<0.05).The symptom scores of the two groups after treatment were all lower than those before treatment(P<0.05).The wound pus color score,wound granulation color score and wound granulation particle score of the observation group were better than those of the control group(P<0.05).(4)The levels of serum TNF-αand IL-6 in the two groups after treatment were lower than those before treatment(P<0.05),and the observation group was superior to the control group(P<0.05).No adverse events were observed in the two groups during the treatment.Conclusion Sanmiao Jiedu Liquid fomentation can improve the local symptoms of limbs in diabetic foot ulcer patients with excessive damp-heat,promote wound healing,and reduce serum TNF-αand IL-6 levels.

关 键 词：糖尿病足溃疡 三妙解毒液 中药溻渍法 临床观察 

分 类 号：R24[医药卫生—中医临床基础]