中医药对男性不育患者疗效的Meta分析  

Meta-analysis of the efficacy of traditional Chinese medicine on male infertility patients

作　　者：刘稳榜 张宸铭[1] 马思成 郝晓慧 陈聪 马瑞敏 周俊豪 LIU Wen-bang;ZHANG Chen-ming;MA Si-cheng;HAO Xiao-hui;CHEN Cong;MA Rui-min;ZHOU Jun-hao(Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,河南郑州450046

出　　处：《时珍国医国药》2024年第7期1754-1758,共5页Lishizhen Medicine and Materia Medica Research

基　　金：中国博士后科学基金(2023T160201,2022M721068);国家自然科学基金(81603632);河南省科技攻关计划(232102311199);河南省自然科学基金(222300420485);河南省高等学校重点科研项目(23A360005);国家中医药临床研究基地专项科研项目(2021JDZX2056);河南省高等学校大学生创新训练计划项目(202210471022,202210471057,202310471011)。

摘　　要：目的运用Meta分析观察中医药对男性不育患者的治疗效果,并进行相应的评价。方法使用计算机检索重庆维普中文科技期刊数据库(VIP)、中国知网(CNKI)、中国学术期刊数据库(万方数据)、Pubmed、EMbase、Cochrane图书馆,检索从开始到结束的时间均为各数据库建库至2022年12月1日,搜集中医药与西药对比治疗男性不育的随机对照试验,由两位研究者按照纳入和排除的标准筛选文献,并将文献中的有关信息纳入。应用REVMAN5.4.1软件进行Meta分析。结果共22篇治疗男性不育的文献被纳入。对1879例病例进行Meta分析结果表明,总有效率[RD=0.22,(95%CI:0.18~0.26),P<0.01]、精子DNA碎片率[MD=-5.84,(95%CI:-6.99~-4.69),P<0.01]、精子总活力[MD=5.90,(95%CI:3.68~8.15),P<0.01]、精子浓度[MD=7.37,(95%CI:4.65~10.1),P<0.01]、前向运动精子百分比[MD=7.50,(95%CI:5.91~9.08),P<0.01]。结论中医药可明显降低患者精子DNA损伤,提高总有效率、精子总活力,并改善了精子浓度、前向运动精子百分比等指标,对男性不育症有良好的治疗效果。Objective To observe and evaluate the therapeutic effect of traditional Chinese medicine on male infertility patients by Meta analysis.Methods Chongqing VIP Chinese Science and Technology Journal Database(VIP),China National Knowledge Infrastructure(CNKI),China Academic Journal Database(Wanfang Data),Pubmed,EMbase,Cochrane Library were searched by computer.The time from the beginning to the end was from the establishment of each database to December 1,2022.Randomized controlled trials(RCTs)of traditional Chinese medicine and Western medicine in the treatment of male infertility were collected.Two researchers screened the literature according to the inclusion and exclusion criteria,and included the relevant information in the literature.Meta-analysis was performed using REVMAN5.4.1 software.Results A total of 22 articles on the treatment of male infertility were included.The results of meta-analysis of 1879 cases showed that.Total effective rate[RD=0.22,(95%CI:0.18~0.26),P<0.01],sperm DNA fragmentation rate[MD=-5.84,(95%CI:-6.99~4.69),P<0.01],total sperm motility[MD=5.90,(95%CI:3.68~8.15),P<0.01],sperm concentration[MD=7.37,(95%CI:4.65~10.1),P<0.01],percentage of forward motile sperm[MD=7.50,(95%CI:5.91~9.08),P<0.01].Conclusion Traditional Chinese medicine can significantly reduce sperm DNA damage,improve total effective rate and total sperm motility,and improve sperm concentration,forward movement sperm percentage and other indicators,which has a good therapeutic effect on male infertility.

关 键 词：精子DNA损伤 精液分析参数 中医药 META分析 男性不育 

分 类 号：R2-03[医药卫生—中医学]