人工半月板支架的分子生物与影像学研究进展  

Advances in molecular biology and imaging of artificial meniscal scaffolds

作　　者：李顺 杨晔 张新涛[1] LI Shun;YANG Ye;ZHANG Xintao(Department of Sports Medicine and Rehabilitation,Peking University Shenzhen Hospital,Shenzhen 518036,China)

机构地区：[1]北京大学深圳医院运动医学与康复医学中心,广东深圳518036

出　　处：《分子影像学杂志》2024年第8期871-875,共5页Journal of Molecular Imaging

基　　金：国家自然科学基金(82272568)。

摘　　要：半月板作为保持膝关节生物力学平衡的重要结构,其再生能力却极为有限。对于不可修复的半月板损伤,传统半月板切除术和同种异体半月板移植都存在局限性。因此基于组织工程的人工半月板支架似乎具有广阔的前景。然而,半月板各向异性的复杂结构、困难的再生过程以及特殊的生物力学性能等诸多挑战仍然是临床应用的障碍。本综述旨在从半月板解剖、生理着手,结合目前半月板损伤的治疗策略,总结人工半月板支架的分子生物学研究进展,以及影像学手段在半月板移植中的应用,以考量其在半月板组织工程中的应用前景及面临的临床转化难题。The meniscus,an important structure for maintaining the biomechanical balance of the knee,has an extremely limited regenerative capacity.In cases of irreparable meniscus injuries,both conventional meniscectomy and meniscus implantation have their limitations.Therefore,artificial meniscus scaffolds based on tissue engineering appear to be promising.However,many challenges such as the complex structure of meniscal anisotropy,the difficult regeneration process and specific biomechanical properties remain barriers to clinical application.The aim of this review is to summarize the progress of molecular biology research on artificial meniscal scaffolds and the application of imaging tools in meniscal transplantation,starting from the anatomy and physiology of the meniscus,and in conjunction with the current therapeutic strategies for meniscus injuries,to consider the prospects for their application in meniscal tissue engineering and the clinical translational challenges they face.

关 键 词：半月板支架 影像学评估 半月板移植 组织工程 

分 类 号：R687.4[医药卫生—骨科学] R816.8[医药卫生—外科学]