GABA代谢及其调控T细胞的作用机制研究进展  

Advances in aspect of GABA metabolism and its regulatory mechanism on T cells

作　　者：姜皓文 樊文梅 JIANG Haowen;FAN Wenmei(School of Basic Medicine,Hebei North University,Zhangjiakou 075000,China;Institute of Urology,the Third Medical Center of Chinese PLA General Hospital,Beijing 100039,China)

机构地区：[1]河北北方学院基础医学院,张家口075000 [2]解放军总医院第三医学中心泌尿外科医学部研究所,北京100039

出　　处：《中国免疫学杂志》2024年第8期1785-1788,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金(81770647,81270509)。

摘　　要：γ-氨基丁酸(GABA)是一种广泛分布的非蛋白质氨基酸,作为一种抑制性神经递质,GABA在脊椎动物神经系统的负向调控环节起重要作用,对维持神经元激发与抑制平衡至关重要。随着持续的探索,发现GABA在免疫系统和免疫细胞发育中的作用同样不可忽视。T细胞是淋巴细胞和免疫系统的重要组成,参与人体的细胞免疫反应,预防疾病、感染和肿瘤的形成。近年来的证据显示,GABA能够抑制T细胞的活化与增殖,参与肿瘤、糖尿病以及自身免疫性疾病的发生发展,但由于GABA-A受体结构的异质性,靶向特定疾病的药物研发还为时尚早。本文将从GABA的代谢、GABA对T细胞的调控作用机制以及GABA与疾病的相关性三个方面阐述GABA的研究进展。Gamma-aminobutyric acid(GABA)is a widely distributed non-protein amino acid.As an inhibitory neurotransmitter,GABA plays an important role in negative regulatory process of vertebrate nervous system,which is essential for maintaining the balance of neuronal stimulation and inhibition.With continued exploration,it was found that GABA in immune system and immune cell development can not be ignored.T cells are important components of lymphocytes and the immune system,and participate in the body's cellular immune response to prevent infection and tumor formation.Evidence in recent years showed that GABA can inhibit T cell activation and proliferation,involve in the development of tumor,diabetes and autoimmune diseases.The development of drugs targeting specific diseases is still far away due to structural heterogeneity of GABA-A receptors.In this review,we will review advances in GABA metabolism,mechanism of action for T cells and its relevance with human diseases.

关 键 词：Γ-氨基丁酸 Γ-氨基丁酸A受体 负向调控 免疫 活化 T细胞 

分 类 号：R392.4[医药卫生—免疫学]