基于网络药理学和分子对接技术探究人参皂苷Rh2治疗肺纤维化的作用机制  

Mechanism of ginsenoside Rh2 in the treatment of pulmonary fibrosis based on network pharmacology and molecular docking

作　　者：焦玉鑫 姜怡先 韩龙哲[3] 孙景鑫 全姬善[1] JIAO Yuxin;JIANG Yixian;HAN Longzhe;SUN Jingxin;QUAN Jishan(College of Pharmacy,Yanbian University,Yanji 133002,China;College of Medicine,Yanbian University,Yanji 133002,China;Yanbian University Hospital,Yanji 133000,China)

机构地区：[1]延边大学药学院,吉林延吉133002 [2]延边大学医学院,吉林延吉133002 [3]延边大学附属医院,吉林延吉133000

出　　处：《延边大学学报（自然科学版）》2024年第2期60-66,共7页Journal of Yanbian University（Natural Science Edition）

基　　金：吉林省教育厅科学技术研究项目(JJKH20220551KJ)。

摘　　要：为了考察人参皂苷Rh2治疗肺纤维化的作用机制,采用网络药理学和分子对接技术探究了人参皂苷Rh2治疗肺纤维化的作用靶点及其作用机制.网络药理学分析显示:人参皂苷Rh2的靶点共有70个,肺纤维化的靶点共有2963个,药物和肺纤维化病的交集基因共有50个,药物治疗肺纤维化的核心靶点共有10个.人参皂苷Rh2治疗肺纤维化的生物学通路和功能分析分别有122条和361条.分子对接结果显示,人参皂苷Rh2与9个核心靶点具有较为稳定的结合活性.研究结果可为后续探究人参皂苷Rh2治疗肺纤维化提供参考.In order to explore the mechanism of ginsenoside Rh2 in the treatment of pulmonary fibrosis,using network pharmacology and molecular docking technique to predict the potential targets.The results of network pharmacology show that ginsenoside Rh2 has 70 targets,pulmonary fibrosis has 2963 targets,50 intersecting genes and 10 core targets for drug treatment of disease.Ginsenoside Rh2 has 122 biological pathways and 361 functional analyses in the treatment of pulmonary fibrosis.The results of molecular docking show that ginsenoside Rh2 exhibit stable binding activity with the nine core targets.These studies suggests that ginsenoside Rh2 may participate in the treatment of pulmonary fibrosis through multiple targets and pathways,and the results of this study can provide references for the subsequent investigation of ginsenoside Rh2 treatment of pulmonary fibrosis.

关 键 词：网络药理学 分子对接技术 人参皂苷RH2 肺纤维化 

分 类 号：R963[医药卫生—微生物与生化药学]