山楂叶总黄酮有效成分及其抗脑缺血作用机制的研究进展  

Research Progress on Total Flavonoid Active Compounds in Hawthorn Leaves and Their Mechanism of Anti-Cerebral Ischemia Effects

作　　者：刘玺 于丽红[2] LIU Xi;YU Lihong(Shandong University of Traditional Chinese Medicine,Jinan 250000,China;The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250000,China)

机构地区：[1]山东中医药大学,山东济南250000 [2]山东中医药大学第二附属医院,山东济南250000

出　　处：《中医药学报》2024年第9期102-106,共5页Acta Chinese Medicine and Pharmacology

基　　金：山东省中医药科技发展计划项目(2015-125);王新陆国医大师传承工作室(鲁财社指〔2022〕36)。

摘　　要：缺血性脑卒中是威胁人类健康的主要疾病之一,具有发病机制复杂、高发病率、高致残率、高死亡率的特点。山楂叶总黄酮(TFHL)是中药山楂叶中最显著的活性成分,在缺血性脑卒中的治疗中效果明显。目前在研究TFHL抗脑缺血作用机制方面已取得较大进展,但由于其作用机制复杂,还需进一步深入研究。因此本文通过系统回顾,从减少细胞凋亡、抗氧化应激、减轻炎症反应、减轻钙离子超载、降低NO神经毒性5个方面对TFHL的抗脑缺血的作用进行综述,并对涉及到的信号通路以及相关药物进行总结,以期为进一步明确TFHL抗脑缺血的作用机制,更大程度开发利用TFHL提供理论依据和参考。Ischemic stroke has always been one of the major diseases threatening human health,which has the characteristics of complex pathogenesis,high morbidity,high disability rate and high mortality rate.Total flavone of hawthorn leaves(TFHL)is the most effective active ingredient in Chinese herbal medicine hawthorn leaves,and it has obvious effect in the treatment of ischemic stroke.At present,great progress has been made in studying the mechanism of TFHL against cerebral ischemia,but due to the complexity of its mechanism,further research is needed.Therefore,this article systematically reviews the anti-ischemic effects of TFHL from five aspects:reducing cell apoptosis,antioxidant stress,alleviating inflammatory response,alleviating calcium overload,and reducing nitric oxide neurotoxicity.Furthermore,this article summarizes the signaling pathways and related drugs,in order to further clarify the mechanism of TFHL's anti ischemic effect and provide theoretical basis and reference for further development and utilization of TFHL.

关 键 词：山楂叶总黄酮 脑缺血 机制 研究进展 

分 类 号：R282.71[医药卫生—中药学]