内耳毛细胞发育与再生关键转录因子的研究进展  

Progress of Research on Key Transcription Factors for Development and Regeneration of Hair Cells

作　　者：苏薇 龚树生[1,2] 王国鹏[1,2] SU Wei;GONG ShuSheng;WANG GuoPeng(Department of Otolaryngology Head and Neck Surgery,Beijing Friendship Hospital,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院耳鼻咽喉头颈外科,北京100050 [2]首都医科大学耳聋疾病临床诊疗与研究中心

出　　处：《中华耳科学杂志》2024年第3期475-479,共5页Chinese Journal of Otology

基　　金：北京市自然科学基金(7212022);国家自然科学基金(82101210)。

摘　　要：内耳毛细胞损伤是感音神经性耳聋和外周性眩晕发生的重要原因之一,由于哺乳动物内耳毛细胞损伤后无法完全再生,因此无法从根本上恢复受损的听力和前庭功能。通过调节与内耳毛细胞发育和成熟相关的关键转录因子,有望实现毛细胞的功能性再生。参与毛细胞发育与再生的转录因子繁多,本文总结了目前毛细胞发育与再生研究领域中涉及的关键转录因子及其相互关系,旨在为未来内耳毛细胞再生研究提供新策略。Damage of hair cells can result in sensorineural hearing loss and vertigo.Because mammalian hair cells cannot regenerate after damage,restoring impaired hearing and vestibular function related to hair cell damage is challenging.Functional regeneration of hair cells may be achieved by regulating key transcription factors involved in the development and maturation of inner ear hair cells.There are many transcription factors involved in hair cell development and regeneration.In this review,key transcription factors and their relationships are summarized in order to provide new strategies for future research on hair cell regeneration.

关 键 词：毛细胞 转录因子 再生 细胞重编程 

分 类 号：R764[医药卫生—耳鼻咽喉科]