替度鲁肽在小儿短肠综合征中的应用研究现状  

Application of teduglutide for pediatric short bowel syndrome

作　　者：蒋维维[1] 马玉君 唐维兵[1] Jiang Weiwei;Ma Yujun;Tang Weibing(Department of Neonatal Surgery,Children's Hospital of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学附属儿童医院新生儿外科,南京210008

出　　处：《中华小儿外科杂志》2024年第8期759-763,共5页Chinese Journal of Pediatric Surgery

基　　金：江苏省卫健委面上项目(M2022037);江苏省卫健委高层次卫生人才“六个一工程”拔尖人才项目资助(LGY2020019);南京市卫健委医药卫生科研课题(YKK20121)。

摘　　要：替度鲁肽(teduglutide,TED)是一种新型重组的胰高血糖素样肽-2(glucagon like pep-tide-2,GLP-2)类似物,GLP-2可促进小肠营养物质转运、增加小肠血流量、促进隐窝细胞增殖、抑制隐窝细胞凋亡和增强小肠屏障功能。短肠综合征(short bowel syndrome,SBS)成人患者应用TED后,肠外营养(parenteral nutrition,PN)的使用时间和剂量均减少。本研究对GLP-2和TED作用机制以及小儿SBS治疗过程中的有效性和安全性进行综述,为国内开展应用TED治疗小儿SBS提供参考。Teduglutide(TED),an analog of intestinotrophic hormone glucagon-like-peptide 2(GLP-2),may facilitate intestinal nutrient transport,boost intestinal blood flow,promote the proliferation of crypt cells,arrest apoptosis of crypt cells and enhance intestinal barrier function.After dosing TED in adults with short bowel syndrome(SBS),duration/dose of parenteral nutrition(PN)declined.This review summarizes the mechanisms of GLP-2 and TED,as well as the effectiveness and safety of TED for pediatric SBS to provide rationales for domestic researches.

关 键 词：短肠综合征 胰高血糖素样肽2 儿童 替度鲁肽 

分 类 号：R725.7[医药卫生—儿科]