Intercontinental spread and clonal expansion of ColRNA1 plasmid-bearing Salmonella Corvallis ST1541 strains:a genomic epidemiological study  

作　　者：Kaichao Chen Miaomiao Xie Han Wang Edward Wai-Chi Chan Sheng Chen 

机构地区：[1]Department of Food Science and Nutrition,Faculty of Science,The Hong Kong Polytechnic University,Kowloon,Hong Kong [2]State Key Lab of Chemical Biology and Drug Discovery,Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Kowloon,Hong Kong [3]Department of Infectious Diseases and Public Health,Jockey Club College of Veterinary Medicine and Life Sciences,City University of Hong Kong,Kowloon,Hong Kong

出　　处：《One Health Advances》2023年第1期198-212,共15页全健康进展（英文）

基　　金：supported by the Key Research and Development Program of Guangdong Province(Grant number,2022B1111040002);the Collaborative Research Fund from Research Grant Council of the Government of Hong Kong SAR(Grant numbers,C7147-20G,C7003-20G).

摘　　要：Salmonella Corvallis ST1541 has recently emerged as a globally disseminated pathogenic strain that often causes severe food-borne infections.Unlike most pandemic serotypes of Salmonella,the ST1541 strains harbored ColRNA1 plasmids that contain qnr-like determinants known to be responsible for the increasing incidence of ciprofloxacin-resistant food-borne Salmonella infections.In this study,we conducted a genomic analysis of a global collection of 388 S.Corvallis ST1541 strains collected within a twenty-year period.We investigated the genetic characteristics of plasmid-mediated quinolone resistance(PMQR)plasmids harbored by these S.Corvallis strains,established a mini-mum spanning tree(MST)to determine the temporal and spatial distribution of the top 10 MST clusters,inferred a time-phylogenies for the major sub-lineages and traced the routes of international dissemination of this serotype strains.Bayesian algorithm predicted that UK might be the origin of S.Corvallis strains currently prevalent in various countries.This idea is supported by the observation of the emergence of intercontinental-disseminated clonal strains and extensive transmission of the extensive-drug resistance(XDR)-encoding plasmid pSA663.This study there-fore provides valuable insight into the evolution of globally transmitted S.Corvallis strains and suggests a need to strengthen cooperation between different countries to control the dissemination of these drug-resistant bacteria.

关 键 词：Salmonella enterica serovar Corvallis Intercontinental spread Plasmid-mediated quinolone resistance Animal food Phylodynamic analysis 

分 类 号：R51[医药卫生—内科学]