Current status and trends of antimicrobial resistance among clinical isolates in China:a retrospective study of CHINET from 2018 to 2022  

作　　者：Weiwei Yang Li Ding Renru Han Dandan Yin Shi Wu Yang Yang Demei Zhu Yan Guo Fupin Hu on behalf of the China Antimicrobial Surveillance Network(CHINET)Study Group 

机构地区：[1]Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai,China [2]Key Laboratory of Clinical Pharmacology of Antibiotics,Ministry of Health,Shanghai,China

出　　处：《One Health Advances》2023年第1期289-297,共9页全健康进展（英文）

基　　金：funded by the National Key Research and Development Program of China(2021YFC2701800 and 2021YFC2701803);the National Natural Science Foundation of China(grant no.81861138052);the China Antimicrobial Surveillance Network(independent medical grants from Pfizer,2018QD100);the Shanghai Antimicrobial Surveillance Network(3030231003).

摘　　要：Antimicrobial resistance(AMR)is a pressing issue in China,with antibiotic therapy becoming less effective against bacterial infections.To address this challenge,the China Antimicrobial Surveillance Network(CHINET)was established in 2005 to monitor antimicrobial resistance in the country.This study analyzed the CHINET data from teaching hospi-tals and evaluated the trends of AMR in China from 2018 to 2022.A range of 163,636 to 301,917 isolates was obtained per year,with the majority being Gram-negative bacilli(69.0%to 71.8%).The proportion of important multidrug-resistant pathogens remained stable over the years.While the analysis showed diverse AMR profiles for different bac-terial species.Over the five years,generally decreased resistance rates were observed from the majority of the tested species.For example,resistance to ceftriaxone decreased in Escherichia coli and Klebsiella pneumoniae,while resistance to imipenem and meropenem decreased in Pseudomonas aeruginosa.Moreover,resistance to methicillin,gentamicin,fosfomycin,and clindamycin also decreased in clinical Staphylococcus aureus isolates.On the other hand,resistance levels of Acinetobacter baumannii remained stable.Our study provides a comprehensive overview of the AMR profiles of common bacterial species in China and highlights the ongoing efforts to address this challenge.

关 键 词：CHINET E.COLI K.pneumoniae P.aeruginosa A.baumannii S.aureus Antimicrobial susceptibility testing 

分 类 号：R97[医药卫生—药品]