Mink infection with influenza A viruses:an ignored intermediate host?  

作　　者：Chris Ka Pun Mok Kun Qin 

机构地区：[1]The Jockey Club School of Public Health and Primary Care,The Chinese University of Hong Kong,SAR,Hong Kong,China [2]Li Ka Shing Institute of Health Sciences,Faculty of Medicine,The Chinese University of Hong Kong,SAR,Hong Kong,China [3]National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention(China CDC),100 Yingxin Street,Western District,100052 Beijing,China

出　　处：《One Health Advances》2023年第1期323-331,共9页全健康进展（英文）

摘　　要：Continuously emergence of human infection with avian influenza A virus poses persistent threat to public health,as illustrated in zoonotic H5N1/6 and H7N9 infections.The recent surge of infection to farmed mink by multiple subtypes of avian influenza A viruses in China highlights the role of mink in the ecology of influenza in this region.Serologic studies suggested that farmed mink in China are frequently infected with prevailing human(H3N2 and H1N1/pdm)and avian(H7N9,H5N6,and H9N2)influenza A viruses.Moreover,genetic analysis from the sequences of influenza viruses from mink showed that several strains acquired mammalian adaptive mutations compared to their avian counterparts.The transmission of SARS-CoV-2 from mink to human alerts us that mink may serve as an intermediate host or reservoir of some emerging pathogens.Considering the high susceptibility to different influenza A viruses,it is possible that mink in endemic regions may play a role as an“mixing vessel”for generating novel pandemic strain.Thus,enhanced surveillance of influenza viruses in mink should be urgently implemented for early warning of potential pandemic.

关 键 词：MINK INFLUENZA PANDEMIC 

分 类 号：S855[农业科学—临床兽医学]