Antimicrobial resistance profiles of Salmonella isolates from human diarrhea cases in China:an eight-year surveilance study  

作　　者：Weiwei Li Haihong Han Jikai Liu Bixia Ke Li Zhan Xiaorong Yang Dongmei Tan Bo Yu Xiang Huo Xiaochen Ma Tongyu Wang Shuai Chen Yong Sun Weiwei Chen Yanfen Li Chengwei Liu Zushun Yang Yunchang Guo 

机构地区：[1]NHC Key Laboratory of Food Safety Risk Assessment,Food Safety Research Unit(2019RU014)of Chinese Academy of Medical Science National Center for Food Safety Risk Assessment,37 Guangqu Road,Chaoyang District,100022 Beijing,People’s Republic of China [2]Guangdong Provincial Center for Disease Control and Prevention,Guangzhou,China [3]Zhejiang Provincial Center for Disease Prevention and Control,Hangzhou,China [4]Sichuan Provincial Center for Disease Control and Prevention,Chengdu,China [5]Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Nanning,China [6]Hubei Provincial Center for Disease Control and Prevention,Wuhan,China [7]Jiangsu Provincial Center for Disease Control and Prevention,Nanjing,China [8]Beijing Center for Disease Control and Prevention,Beijing,China [9]Hunan Provincial Center for Disease Control and Prevention,Changsha,China [10]Anhui Provincial Center for Disease Control and Prevention,Hefei,China [11]Fujian Provincial Center for Disease Control and Prevention,Fuzhou,China [12]Henan Provincial Center for Disease Control and Prevention,Zhengzhou,China [13]Jiangxi Provincial Center for Disease Control and Prevention,Nanchang,China [14]Yunnan Provincial Center for Disease Control and Prevention,Kunming,China

出　　处：《One Health Advances》2023年第1期353-360,共8页全健康进展（英文）

基　　金：supported by The National Key Research and Development Program of China(Grant number 2022YFC2303900).

摘　　要：Salmonella is widely known as one of the most common foodborne pathogens,and antibiotics remain effective in clinical therapies against its infections.To guide better clinical antibiotic treatment,we analyzed the antimicrobial resistance(AMR)profiles of a nation-wide collection of 36,822 Salmonella isolates derived from sporadic diarrhea cases in China from 2014 to 2021.A panel of 15 antibiotics,including 10 critically important and 5 highly important antimicrobial agents for human medicine based on the WHO CIA List,was selected for AMR surveillance.Salmonella enterica serovar Typhimurium,Enteritidis,I 4,[5],12:i:-,London,and Stanley were turns to be the top five serotypes from human diarrhea cases in China.Antimicrobial susceptibility testing revealed that the majority of the isolates(87.2%)were resistant to at least one antimicrobial agent,and 66.5%were multidrug resistant(MDR).Salmonella isolates were found to be highly resistant to ampicillin(73.4%)while sensitive to imipenem(98.73%).Over the eight years,the isolates were demonstrated generally an increase in resistance to ampicillin,chloramphenicol,trimethoprim-sulfameth-oxazole,and azithromycin,but displayed varied resistance profiles in terms of serotypes.Stanley(0.66-27.18%)and Agona(0.78-45.30%)had lower resistance rates compared to Typhimurium(1.11-85.6%),Enteritidis(1.55-91.29%),and I 4,[5],12:i:-(1.02-94.28%).In conclusion,our results provide systematic data on the resistance characteristics of Salmonella isolates from human diarrhea cases in China.Furthermore,this data identifies priorities for the clinical treatments of antibiotics.

关 键 词：Foodborne disease SALMONELLA Antimicrobial resistance 

分 类 号：R37[医药卫生—病原生物学]